Clinical impact of leukemic blast heterogeneity at diagnosis in cytogenetic intermediate-risk acute myeloid leukemia

Marianne Hutchings Hoffmann; Tobias Wirenfeldt Klausen; Martin Boegsted; Steffen Falgreen Larsen; Alexander Schmitz; Eva Birgitte Leinøe; Kjeld Schmiegelow; Henrik Hasle; Olav Jonas Bergmann; Suzette Sorensen; Mette Nyegaard; Karen Dybkaer; Hans Erik Johnsen

doi:10.1002/cyto.b.20633

Clinical impact of leukemic blast heterogeneity at diagnosis in cytogenetic intermediate-risk acute myeloid leukemia

Marianne Hutchings Hoffmann, Tobias Wirenfeldt Klausen, Martin Boegsted, Steffen Falgreen Larsen, Alexander Schmitz, Eva Birgitte Leinøe, Kjeld Schmiegelow, Henrik Hasle, Olav Jonas Bergmann, Suzette Sorensen, Mette Nyegaard, Karen Dybkaer, Hans Erik Johnsen

Department of Paediatrics and Adolescent Medicine

11 Citations (Scopus)

Abstract

Individual cellular heterogeneity within the acute myeloid leukemia (AML) bone marrow samples can be observed by multi parametric flow cytometry analysis (MFC) indicating that immunophenotypic screening for leukemic blast subsets may have prognostic impact.

Original language	English
Journal	Cytometry. Part B: Clinical Cytometry
Volume	82
Issue number	3
Pages (from-to)	123-31
Number of pages	9
ISSN	1552-4949
DOIs	https://doi.org/10.1002/cyto.b.20633
Publication status	Published - 2012

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Antigens, CD14
Antigens, CD45
Antigens, CD58
Antigens, Surface
Bone Marrow Cells
Bone Marrow Examination
Child
Child, Preschool
Female
Flow Cytometry
Humans
Immunophenotyping
Leukemia, Myeloid, Acute
Male
Middle Aged
Prognosis
Proto-Oncogene Proteins c-kit
Tumor Markers, Biological
Young Adult

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Hoffmann, M. H., Klausen, T. W., Boegsted, M., Larsen, S. F., Schmitz, A., Leinøe, E. B., Schmiegelow, K., Hasle, H., Bergmann, O. J., Sorensen, S., Nyegaard, M., Dybkaer, K., & Johnsen, H. E. (2012). Clinical impact of leukemic blast heterogeneity at diagnosis in cytogenetic intermediate-risk acute myeloid leukemia. Cytometry. Part B: Clinical Cytometry, 82(3), 123-31. https://doi.org/10.1002/cyto.b.20633

Hoffmann, MH, Klausen, TW, Boegsted, M, Larsen, SF, Schmitz, A, Leinøe, EB , Schmiegelow, K, Hasle, H, Bergmann, OJ, Sorensen, S, Nyegaard, M, Dybkaer, K & Johnsen, HE 2012, 'Clinical impact of leukemic blast heterogeneity at diagnosis in cytogenetic intermediate-risk acute myeloid leukemia', Cytometry. Part B: Clinical Cytometry, vol. 82, no. 3, pp. 123-31. https://doi.org/10.1002/cyto.b.20633

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title = "Clinical impact of leukemic blast heterogeneity at diagnosis in cytogenetic intermediate-risk acute myeloid leukemia",

abstract = "Individual cellular heterogeneity within the acute myeloid leukemia (AML) bone marrow samples can be observed by multi parametric flow cytometry analysis (MFC) indicating that immunophenotypic screening for leukemic blast subsets may have prognostic impact.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Antigens, CD14, Antigens, CD45, Antigens, CD58, Antigens, Surface, Bone Marrow Cells, Bone Marrow Examination, Child, Child, Preschool, Female, Flow Cytometry, Humans, Immunophenotyping, Leukemia, Myeloid, Acute, Male, Middle Aged, Prognosis, Proto-Oncogene Proteins c-kit, Tumor Markers, Biological, Young Adult",

author = "Hoffmann, \{Marianne Hutchings\} and Klausen, \{Tobias Wirenfeldt\} and Martin Boegsted and Larsen, \{Steffen Falgreen\} and Alexander Schmitz and Lein{\o}e, \{Eva Birgitte\} and Kjeld Schmiegelow and Henrik Hasle and Bergmann, \{Olav Jonas\} and Suzette Sorensen and Mette Nyegaard and Karen Dybkaer and Johnsen, \{Hans Erik\}",

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year = "2012",

doi = "10.1002/cyto.b.20633",

language = "English",

volume = "82",

pages = "123--31",

journal = "Cytometry. Part B: Clinical Cytometry",

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T1 - Clinical impact of leukemic blast heterogeneity at diagnosis in cytogenetic intermediate-risk acute myeloid leukemia

AU - Hoffmann, Marianne Hutchings

AU - Klausen, Tobias Wirenfeldt

AU - Boegsted, Martin

AU - Larsen, Steffen Falgreen

AU - Schmitz, Alexander

AU - Leinøe, Eva Birgitte

AU - Schmiegelow, Kjeld

AU - Hasle, Henrik

AU - Bergmann, Olav Jonas

AU - Sorensen, Suzette

AU - Nyegaard, Mette

AU - Dybkaer, Karen

AU - Johnsen, Hans Erik

PY - 2012

Y1 - 2012

N2 - Individual cellular heterogeneity within the acute myeloid leukemia (AML) bone marrow samples can be observed by multi parametric flow cytometry analysis (MFC) indicating that immunophenotypic screening for leukemic blast subsets may have prognostic impact.

AB - Individual cellular heterogeneity within the acute myeloid leukemia (AML) bone marrow samples can be observed by multi parametric flow cytometry analysis (MFC) indicating that immunophenotypic screening for leukemic blast subsets may have prognostic impact.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antigens, CD14

KW - Antigens, CD45

KW - Antigens, CD58

KW - Antigens, Surface

KW - Bone Marrow Cells

KW - Bone Marrow Examination

KW - Child

KW - Child, Preschool

KW - Female

KW - Flow Cytometry

KW - Humans

KW - Immunophenotyping

KW - Leukemia, Myeloid, Acute

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Proto-Oncogene Proteins c-kit

KW - Tumor Markers, Biological

KW - Young Adult

UR - https://www.scopus.com/pages/publications/84860212072

U2 - 10.1002/cyto.b.20633

DO - 10.1002/cyto.b.20633

M3 - Journal article

C2 - 22328535

SN - 1552-4949

VL - 82

SP - 123

EP - 131

JO - Cytometry. Part B: Clinical Cytometry

JF - Cytometry. Part B: Clinical Cytometry

IS - 3

ER -

Clinical impact of leukemic blast heterogeneity at diagnosis in cytogenetic intermediate-risk acute myeloid leukemia

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Keywords

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