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Clinical effect of Diskus dry-powder inhaler at low and high inspiratory flow-rates in asthmatic children

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In vitro studies with the Diskus inhaler at low and high flow rates show consistent doses of drug as fine particles <4.7 microm. The present study was designed to ascertain whether this in vitro flow independency translates into flow-independent clinical effect when the device is used by patients at low (30 L x min[-1]) and high (90 L x min[-1]) flow rates. A pilot study in 129 children aged 3-10 yrs demonstrated that 99% of children of 3 yrs and above can generate a flow > or = 30 L x min(-1) through the device, while 26% performed > or = 90 L x min(-1). Eighteen children aged 8-15 yrs with exercise induced asthma inhaled placebo or salmeterol 50 microg at either 30 L x min(-1) or 90 L x min(-1). Exercise challenges were carried out 1 h and 12 h after dosing. The maximum percentage fall in forced expiratory volume in one second (FEVI) after exercise 12 h after treatment was significantly less after salmeterol at either flow rates as compared to placebo. There was no significant difference in the protection from salmeterol on the day of low-flow inhalation versus the day of high-flow inhalation. Consistent in vitro fine particle dosing from the Diskus inhaler translates into a consistent clinical effect at low and high flow rates in children.

Original languageEnglish
JournalEuropean Respiratory Journal
Volume11
Issue number2
Pages (from-to)350-4
Number of pages5
ISSN0903-1936
Publication statusPublished - Feb 1998

    Research areas

  • Adolescent, Albuterol, Asthma, Exercise-Induced, Bronchoconstriction, Bronchodilator Agents, Child, Cross-Over Studies, Double-Blind Method, Exercise, Female, Forced Expiratory Volume, Humans, Male, Nebulizers and Vaporizers, Powders, Pulmonary Ventilation

ID: 45785219