Clinical considerations and pitfalls in the use of depot antipsychotics

Niels August Willer Strand; Mette Ødegaard Nielsen; Jimmi Nielsen

doi:10.61409/V12230776

Clinical considerations and pitfalls in the use of depot antipsychotics

Translated title of the contribution: Not Available

Niels August Willer Strand, Mette Ødegaard Nielsen, Jimmi Nielsen

Abstract

Long-acting injectable antipsychotics (LAI) is a frequently used treatment modality which has advantages over oral antipsychotics regarding hospitalization or relapse prevention. However, the pharmacokinetic properties of LAI greatly differ from oral antipsychotics. This necessitates an increased knowledge about LAI among clinicians, especially when commencing treatment, changing doses and discontinuing treatment. In this review, we summarize an array of clinically important characteristics of LAI and give a conceptual framework for understanding the pharmacokinetics of LAI.

Translated title of the contribution	Not Available
Original language	Danish
Article number	V12230776
Journal	Ugeskrift for Laeger
Volume	186
Issue number	20
ISSN	0041-5782
DOIs	https://doi.org/10.61409/V12230776
Publication status	Published - 13 May 2024

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10.61409/V12230776

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title = "Clinical considerations and pitfalls in the use of depot antipsychotics",

abstract = "Long-acting injectable antipsychotics (LAI) is a frequently used treatment modality which has advantages over oral antipsychotics regarding hospitalization or relapse prevention. However, the pharmacokinetic properties of LAI greatly differ from oral antipsychotics. This necessitates an increased knowledge about LAI among clinicians, especially when commencing treatment, changing doses and discontinuing treatment. In this review, we summarize an array of clinically important characteristics of LAI and give a conceptual framework for understanding the pharmacokinetics of LAI.",

keywords = "Humans, Antipsychotic Agents/administration \& dosage, Delayed-Action Preparations, Injections, Injections, Intramuscular",

author = "Strand, \{Niels August Willer\} and Nielsen, \{Mette {\O}degaard\} and Jimmi Nielsen",

note = "Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.",

year = "2024",

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T1 - Clinical considerations and pitfalls in the use of depot antipsychotics

AU - Strand, Niels August Willer

AU - Nielsen, Mette Ødegaard

AU - Nielsen, Jimmi

N1 - Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

PY - 2024/5/13

Y1 - 2024/5/13

N2 - Long-acting injectable antipsychotics (LAI) is a frequently used treatment modality which has advantages over oral antipsychotics regarding hospitalization or relapse prevention. However, the pharmacokinetic properties of LAI greatly differ from oral antipsychotics. This necessitates an increased knowledge about LAI among clinicians, especially when commencing treatment, changing doses and discontinuing treatment. In this review, we summarize an array of clinically important characteristics of LAI and give a conceptual framework for understanding the pharmacokinetics of LAI.

AB - Long-acting injectable antipsychotics (LAI) is a frequently used treatment modality which has advantages over oral antipsychotics regarding hospitalization or relapse prevention. However, the pharmacokinetic properties of LAI greatly differ from oral antipsychotics. This necessitates an increased knowledge about LAI among clinicians, especially when commencing treatment, changing doses and discontinuing treatment. In this review, we summarize an array of clinically important characteristics of LAI and give a conceptual framework for understanding the pharmacokinetics of LAI.

KW - Humans

KW - Antipsychotic Agents/administration & dosage

KW - Delayed-Action Preparations

KW - Injections

KW - Injections, Intramuscular

UR - https://www.scopus.com/pages/publications/85194868874

U2 - 10.61409/V12230776

DO - 10.61409/V12230776

M3 - Review

C2 - 38808759

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VL - 186

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 20

M1 - V12230776

ER -

Clinical considerations and pitfalls in the use of depot antipsychotics

Abstract

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