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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Clinical care of adult Turner syndrome--new aspects

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Adult Growth Hormone Deficiency: from Transition to Senescence

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Alpha-mannosidosis - a review of genetic, clinical findings and options of treatment

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Surgical treatment and follow up on undescended testis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The role of growth hormone in the pathogenesis of diabetic kidney disease

    Research output: Contribution to journalReviewResearchpeer-review

  1. Effect of dosage of 17ß-estradiol on uterine growth in Turner syndrome - a randomized controlled clinical pilot trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Androgen insensitivity syndrome discovered due to discordance in prenatal assessments of fetal gender

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Five-Year Randomized Study Demonstrates Blood Pressure Increases in Young Women With Turner Syndrome Regardless of Estradiol Dose

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Transition in Pediatric and Adolescent Hypogonadal Girls: Gynecological Aspects, Estrogen Replacement Therapy, and Contraception

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  • Christian Trolle
  • Kristian Havmand Mortensen
  • Britta Eilersen Hjerrild
  • Line Cleemann
  • Claus Højbjerg Gravholt
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Turner syndrome (TS) is characterized by numerous medical challenges during adolescence and adulthood. Puberty has to be induced in most cases, and female sex hormone replacement therapy (HRT) should continue during adult years. These issues are normally dealt with by the paediatrician, but once a TS female enters adulthood it is less clear who should be the primary care giver. Morbidity and mortality is increased, especially due to the risk of dissection of the aorta and other cardiovascular diseases, as well as the risk of type 2 diabetes, hypertension, osteoporosis, thyroid disease and other diseases. The proper dose of HRT with female sex steroids has not been established, and, likewise, benefits and/or drawbacks from HRT have not been thoroughly evaluated. The transition period from paediatric to adult care seems to be especially vulnerable and the proper framework for transition has not yet been established. Likewise, no framework is in place for continuous follow-up during adult years in many countries. Today, most treatment recommendations are based on expert opinion and are unfortunately not evidence based, although more areas, such as growth hormone and oxandrolone treatment for increasing height, are becoming well founded. Osteoporosis, diabetes, both type 1 and 2, hypothyroidism, obesity and a host of other endocrine diseases and conditions are seen more frequently in TS. Prevention, intervention and proper treatment is only just being recognized. Hypertension is frequent and can be a forerunner of cardiovascular disease. The description of adult life with TS has been broadened and medical, social and psychological aspects are being added at a compelling pace. Proper care during adulthood should be studied and a framework for care should be in place, since most morbidity potentially is amenable to intervention. In summary, TS is a condition associated with a number of diseases and conditions which need the attention of a multi-disciplinary team during adulthood.
Original languageEnglish
JournalPediatric Endocrinology Reviews
Volume9
Issue numbersuppl 2
Pages (from-to)739-49
Number of pages11
ISSN1565-4753
Publication statusPublished - 2012

    Research areas

  • Adult, Cardiovascular Diseases, Diabetes Mellitus, Female, Humans, Liver Diseases, Osteoporosis, Primary Ovarian Insufficiency, Thyroid Diseases, Transition to Adult Care, Turner Syndrome

ID: 36456045