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Clinical and epidemiologic characteristics of human bocavirus in Danish infants: results from a prospective birth cohort study

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@article{0c32725b3f96412aa5502bc727588348,
title = "Clinical and epidemiologic characteristics of human bocavirus in Danish infants: results from a prospective birth cohort study",
abstract = "BACKGROUND: Human bocavirus (HBoV) is a recently discovered parvovirus that has been detected in respiratory samples from children with acute respiratory tract infection (ARTI) and in feces from children with gastroenteritis. However, its role as a causative agent of respiratory disease is not determined. METHODS: We investigated the presence of HBoV by real-time polymerase-chain reaction of nasal swab specimens obtained from 228 healthy children followed in the community from birth to 1 year of age for a 2-year period from 2004 to 2006. Nasal swabs and symptom diaries were collected at monthly home visits. RESULTS: HBoV was detected in 57 (8.2{\%}) of 697 nasal swab specimens from children with ARTI, in 1 (2.3{\%}) of 44 swabs from children with diarrhea, and in 13 (8.6{\%}) of 152 swabs from asymptomatic children. HBoV was present mainly during the winter months. An additional respiratory virus was identified in 27 (47.4{\%}) HBoV-positive samples. Thirty-four (68{\%}) of 50 children with ARTI shed HBoV for less than 1 month, 13 (26{\%}) for 2 months, 2 (4{\%}) for 3 months, and 1 (2{\%}) for 4 months. Seven asymptomatic children shed HBoV for less than 1 month, 2 children for 2 months, and 1 asymptomatic child had 5 HBoV-positive nasal swabs detected for 6 consecutive months. HBoV infection was associated with maternal smoking, being born in the winter, and predisposition to asthma. CONCLUSIONS: Asymptomatic carriage of HBoV is common in infants <1 year of age, and an HBoV-positive test result does not imply that HBoV is the cause of the illness.",
keywords = "Acute Disease, Bocavirus, Child, Preschool, Cohort Studies, Denmark, Diarrhea, Female, Humans, Infant, Infant, Newborn, Male, Nose, Parvoviridae Infections, Polymerase Chain Reaction, Respiratory Tract Infections, Risk Factors, Virus Shedding",
author = "{von Linstow}, Marie-Louise and Mette H{\o}gh and Birthe H{\o}gh",
year = "2008",
doi = "10.1097/INF.0b013e3181757b16",
language = "English",
volume = "27",
pages = "897--902",
journal = "Pediatric Infectious Disease Journal",
issn = "0891-3668",
publisher = "Lippincott Williams & Wilkins",
number = "10",

}

RIS

TY - JOUR

T1 - Clinical and epidemiologic characteristics of human bocavirus in Danish infants: results from a prospective birth cohort study

AU - von Linstow, Marie-Louise

AU - Høgh, Mette

AU - Høgh, Birthe

PY - 2008

Y1 - 2008

N2 - BACKGROUND: Human bocavirus (HBoV) is a recently discovered parvovirus that has been detected in respiratory samples from children with acute respiratory tract infection (ARTI) and in feces from children with gastroenteritis. However, its role as a causative agent of respiratory disease is not determined. METHODS: We investigated the presence of HBoV by real-time polymerase-chain reaction of nasal swab specimens obtained from 228 healthy children followed in the community from birth to 1 year of age for a 2-year period from 2004 to 2006. Nasal swabs and symptom diaries were collected at monthly home visits. RESULTS: HBoV was detected in 57 (8.2%) of 697 nasal swab specimens from children with ARTI, in 1 (2.3%) of 44 swabs from children with diarrhea, and in 13 (8.6%) of 152 swabs from asymptomatic children. HBoV was present mainly during the winter months. An additional respiratory virus was identified in 27 (47.4%) HBoV-positive samples. Thirty-four (68%) of 50 children with ARTI shed HBoV for less than 1 month, 13 (26%) for 2 months, 2 (4%) for 3 months, and 1 (2%) for 4 months. Seven asymptomatic children shed HBoV for less than 1 month, 2 children for 2 months, and 1 asymptomatic child had 5 HBoV-positive nasal swabs detected for 6 consecutive months. HBoV infection was associated with maternal smoking, being born in the winter, and predisposition to asthma. CONCLUSIONS: Asymptomatic carriage of HBoV is common in infants <1 year of age, and an HBoV-positive test result does not imply that HBoV is the cause of the illness.

AB - BACKGROUND: Human bocavirus (HBoV) is a recently discovered parvovirus that has been detected in respiratory samples from children with acute respiratory tract infection (ARTI) and in feces from children with gastroenteritis. However, its role as a causative agent of respiratory disease is not determined. METHODS: We investigated the presence of HBoV by real-time polymerase-chain reaction of nasal swab specimens obtained from 228 healthy children followed in the community from birth to 1 year of age for a 2-year period from 2004 to 2006. Nasal swabs and symptom diaries were collected at monthly home visits. RESULTS: HBoV was detected in 57 (8.2%) of 697 nasal swab specimens from children with ARTI, in 1 (2.3%) of 44 swabs from children with diarrhea, and in 13 (8.6%) of 152 swabs from asymptomatic children. HBoV was present mainly during the winter months. An additional respiratory virus was identified in 27 (47.4%) HBoV-positive samples. Thirty-four (68%) of 50 children with ARTI shed HBoV for less than 1 month, 13 (26%) for 2 months, 2 (4%) for 3 months, and 1 (2%) for 4 months. Seven asymptomatic children shed HBoV for less than 1 month, 2 children for 2 months, and 1 asymptomatic child had 5 HBoV-positive nasal swabs detected for 6 consecutive months. HBoV infection was associated with maternal smoking, being born in the winter, and predisposition to asthma. CONCLUSIONS: Asymptomatic carriage of HBoV is common in infants <1 year of age, and an HBoV-positive test result does not imply that HBoV is the cause of the illness.

KW - Acute Disease

KW - Bocavirus

KW - Child, Preschool

KW - Cohort Studies

KW - Denmark

KW - Diarrhea

KW - Female

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Nose

KW - Parvoviridae Infections

KW - Polymerase Chain Reaction

KW - Respiratory Tract Infections

KW - Risk Factors

KW - Virus Shedding

U2 - 10.1097/INF.0b013e3181757b16

DO - 10.1097/INF.0b013e3181757b16

M3 - Journal article

VL - 27

SP - 897

EP - 902

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

SN - 0891-3668

IS - 10

ER -

ID: 32577308