Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Classification of patients referred under suspicion of tick-borne diseases, Copenhagen, Denmark

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Changes in Lyme neuroborreliosis incidence in Denmark, 1996 to 2015

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Lyme neuroborreliosis in adults: A nationwide prospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Emerging tick-borne pathogens in the Nordic countries: A clinical and laboratory follow-up study of high-risk tick-bitten individuals

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Rickettsioses in Denmark: A retrospective survey of clinical features and travel history

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Effects of nutritional supplementation on glucose metabolism and insulin function among people with HIV initiating ART

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Central and peripheral nervous system complications of COVID-19: a prospective tertiary center cohort with 3-month follow-up

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Enterovirus Meningitis in Adults: A Prospective Nationwide Population-Based Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The Danish HIV Birth Cohort (DHBC) - a nationwide, prospective cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. A case of thrombocytopenia and multiple thromboses after vaccination with ChAdOx1 nCoV-19 against SARS-CoV-2

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

To provide better care for patients suspected of having a tick-transmitted infection, the Clinic for Tick-borne Diseases at Rigshospitalet, Copenhagen, Denmark was established. The aim of this prospective cohort study was to evaluate diagnostic outcome and to characterize demographics and clinical presentations of patients referred between the 1st of September 2017 to 31st of August 2019. A diagnosis of Lyme borreliosis was based on medical history, symptoms, serology and cerebrospinal fluid analysis. The patients were classified as definite Lyme borreliosis, possible Lyme borreliosis or post-treatment Lyme disease syndrome. Antibiotic treatment of Lyme borreliosis manifestations was initiated in accordance with the national guidelines. Patients not fulfilling the criteria of Lyme borreliosis were further investigated and discussed with an interdisciplinary team consisting of specialists from relevant specialties, according to individual clinical presentation and symptoms. Clinical information and demographics were registered and managed in a database. A total of 215 patients were included in the study period. Median age was 51 years (range 17-83 years), and 56 % were female. Definite Lyme borreliosis was diagnosed in 45 patients, of which 20 patients had erythema migrans, 14 patients had definite Lyme neuroborreliosis, six had acrodermatitis chronica atrophicans, four had multiple erythema migrans and one had Lyme carditis. Furthermore, 12 patients were classified as possible Lyme borreliosis and 12 patients as post-treatment Lyme disease syndrome. A total of 146 patients (68 %) did not fulfil the diagnostic criteria of Lyme borreliosis. Half of these patients (73 patients, 34 %) were diagnosed with an alternative diagnosis including inflammatory diseases, cancer diseases and two patients with a tick-associated disease other than Lyme borreliosis. A total of 73 patients (34 %) were discharged without sign of somatic disease. Lyme borreliosis patients had a shorter duration of symptoms prior to the first hospital encounter compared to patients discharged without a specific diagnosis (p<0.001). When comparing symptoms at presentation, patients discharged without a specific diagnosis suffered more often from general fatigue and cognitive dysfunction. In conclusion, 66 % of all referred patients were given a specific diagnosis after ended outpatient course. A total of 32 % was diagnosed with either definite Lyme borreliosis, possible Lyme borreliosis or post-treatment Lyme disease syndrome; 34 % was diagnosed with a non-tick-associated diagnosis. Our findings underscore the complexity in diagnosing Lyme borreliosis and the importance of ruling out other diseases through careful examination.

Original languageEnglish
Article number101591
JournalTicks and Tick-borne Diseases
Volume12
Issue number1
ISSN1877-959X
DOIs
Publication statusPublished - Jan 2021

    Research areas

  • (Max 6): Lyme borreliosis, Adults, Borrelia burgdorferi sensu lato complex, Multidisciplinary approach

ID: 62292380