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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Citrate NMR peak irreproducibility in blood samples after reacquisition of spectra

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BACKGROUND: In our metabolomics studies we have noticed that repeated NMR acquisition on the same sample can result in altered metabolite signal intensities.

AIMS: To investigate the reproducibility of repeated NMR acquisition on selected metabolites in serum and plasma from two large human metabolomics studies.

METHODS: Two peak regions for each metabolite were integrated and changes occurring after reacquisition were correlated.

RESULTS: Integral changes were generally small, but serum citrate signals decreased significantly in some samples.

CONCLUSIONS: Several metabolite integrals were not reproducible in some of the repeated spectra. Following established protocols, randomising analysis order and biomarker validation are important.

Original languageEnglish
JournalMetabolomics
Volume16
Issue number1
Pages (from-to)7
ISSN1573-3882
DOIs
Publication statusPublished - 2019

ID: 58987242