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Circulating metabolites in progression to islet autoimmunity and type 1 diabetes

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Lamichhane, S, Kemppainen, E, Trošt, K, Siljander, H, Hyöty, H, Ilonen, J, Toppari, J, Veijola, R, Hyötyläinen, T, Knip, M & Orešič, M 2019, 'Circulating metabolites in progression to islet autoimmunity and type 1 diabetes' Diabetologia, vol. 62, no. 12, pp. 2287-2297. https://doi.org/10.1007/s00125-019-04980-0

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CBE

MLA

Vancouver

Lamichhane S, Kemppainen E, Trošt K, Siljander H, Hyöty H, Ilonen J et al. Circulating metabolites in progression to islet autoimmunity and type 1 diabetes. Diabetologia. 2019 Dec;62(12):2287-2297. https://doi.org/10.1007/s00125-019-04980-0

Author

Lamichhane, Santosh ; Kemppainen, Esko ; Trošt, Kajetan ; Siljander, Heli ; Hyöty, Heikki ; Ilonen, Jorma ; Toppari, Jorma ; Veijola, Riitta ; Hyötyläinen, Tuulia ; Knip, Mikael ; Orešič, Matej. / Circulating metabolites in progression to islet autoimmunity and type 1 diabetes. In: Diabetologia. 2019 ; Vol. 62, No. 12. pp. 2287-2297.

Bibtex

@article{93df294bdd3343e2b399d9a066a141d1,
title = "Circulating metabolites in progression to islet autoimmunity and type 1 diabetes",
abstract = "AIMS/HYPOTHESIS: Metabolic dysregulation may precede the onset of type 1 diabetes. However, these metabolic disturbances and their specific role in disease initiation remain poorly understood. In this study, we examined whether children who progress to type 1 diabetes have a circulatory polar metabolite profile distinct from that of children who later progress to islet autoimmunity but not type 1 diabetes and a matched control group.METHODS: We analysed polar metabolites from 415 longitudinal plasma samples in a prospective cohort of children in three study groups: those who progressed to type 1 diabetes; those who seroconverted to one islet autoantibody but not to type 1 diabetes; and an antibody-negative control group. Metabolites were measured using two-dimensional GC high-speed time of flight MS.RESULTS: In early infancy, progression to type 1 diabetes was associated with downregulated amino acids, sugar derivatives and fatty acids, including catabolites of microbial origin, compared with the control group. Methionine remained persistently upregulated in those progressing to type 1 diabetes compared with the control group and those who seroconverted to one islet autoantibody. The appearance of islet autoantibodies was associated with decreased glutamic and aspartic acids.CONCLUSIONS/INTERPRETATION: Our findings suggest that children who progress to type 1 diabetes have a unique metabolic profile, which is, however, altered with the appearance of islet autoantibodies. Our findings may assist with early prediction of the disease.",
keywords = "Beta cell autoimmunity, Metabolomics, Type 1 diabetes",
author = "Santosh Lamichhane and Esko Kemppainen and Kajetan Trošt and Heli Siljander and Heikki Hy{\"o}ty and Jorma Ilonen and Jorma Toppari and Riitta Veijola and Tuulia Hy{\"o}tyl{\"a}inen and Mikael Knip and Matej Orešič",
year = "2019",
month = "12",
doi = "10.1007/s00125-019-04980-0",
language = "English",
volume = "62",
pages = "2287--2297",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "12",

}

RIS

TY - JOUR

T1 - Circulating metabolites in progression to islet autoimmunity and type 1 diabetes

AU - Lamichhane, Santosh

AU - Kemppainen, Esko

AU - Trošt, Kajetan

AU - Siljander, Heli

AU - Hyöty, Heikki

AU - Ilonen, Jorma

AU - Toppari, Jorma

AU - Veijola, Riitta

AU - Hyötyläinen, Tuulia

AU - Knip, Mikael

AU - Orešič, Matej

PY - 2019/12

Y1 - 2019/12

N2 - AIMS/HYPOTHESIS: Metabolic dysregulation may precede the onset of type 1 diabetes. However, these metabolic disturbances and their specific role in disease initiation remain poorly understood. In this study, we examined whether children who progress to type 1 diabetes have a circulatory polar metabolite profile distinct from that of children who later progress to islet autoimmunity but not type 1 diabetes and a matched control group.METHODS: We analysed polar metabolites from 415 longitudinal plasma samples in a prospective cohort of children in three study groups: those who progressed to type 1 diabetes; those who seroconverted to one islet autoantibody but not to type 1 diabetes; and an antibody-negative control group. Metabolites were measured using two-dimensional GC high-speed time of flight MS.RESULTS: In early infancy, progression to type 1 diabetes was associated with downregulated amino acids, sugar derivatives and fatty acids, including catabolites of microbial origin, compared with the control group. Methionine remained persistently upregulated in those progressing to type 1 diabetes compared with the control group and those who seroconverted to one islet autoantibody. The appearance of islet autoantibodies was associated with decreased glutamic and aspartic acids.CONCLUSIONS/INTERPRETATION: Our findings suggest that children who progress to type 1 diabetes have a unique metabolic profile, which is, however, altered with the appearance of islet autoantibodies. Our findings may assist with early prediction of the disease.

AB - AIMS/HYPOTHESIS: Metabolic dysregulation may precede the onset of type 1 diabetes. However, these metabolic disturbances and their specific role in disease initiation remain poorly understood. In this study, we examined whether children who progress to type 1 diabetes have a circulatory polar metabolite profile distinct from that of children who later progress to islet autoimmunity but not type 1 diabetes and a matched control group.METHODS: We analysed polar metabolites from 415 longitudinal plasma samples in a prospective cohort of children in three study groups: those who progressed to type 1 diabetes; those who seroconverted to one islet autoantibody but not to type 1 diabetes; and an antibody-negative control group. Metabolites were measured using two-dimensional GC high-speed time of flight MS.RESULTS: In early infancy, progression to type 1 diabetes was associated with downregulated amino acids, sugar derivatives and fatty acids, including catabolites of microbial origin, compared with the control group. Methionine remained persistently upregulated in those progressing to type 1 diabetes compared with the control group and those who seroconverted to one islet autoantibody. The appearance of islet autoantibodies was associated with decreased glutamic and aspartic acids.CONCLUSIONS/INTERPRETATION: Our findings suggest that children who progress to type 1 diabetes have a unique metabolic profile, which is, however, altered with the appearance of islet autoantibodies. Our findings may assist with early prediction of the disease.

KW - Beta cell autoimmunity

KW - Metabolomics

KW - Type 1 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85070968581&partnerID=8YFLogxK

U2 - 10.1007/s00125-019-04980-0

DO - 10.1007/s00125-019-04980-0

M3 - Journal article

VL - 62

SP - 2287

EP - 2297

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 12

ER -

ID: 57975789