Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Chylomicronemia risk factors ranked by importance for the individual and community in 108 711 women and men

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Coffee intake protects against symptomatic gallstone disease in the general population: a Mendelian randomization study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Women Living with HIV in high-income settings and Breastfeeding

    Research output: Contribution to journalReviewResearchpeer-review

  3. Effectiveness of maternal immunization with trivalent inactivated influenza vaccine in pregnant women and their infants

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Phenotypic and genotypic differences between Indian and Scandinavian women with gestational diabetes mellitus

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Quantifying atherogenic lipoproteins for lipid-lowering strategies: Consensus-based recommendations from EAS and EFLM

    Research output: Contribution to journalReviewResearchpeer-review

  2. Reply to: Clinical impact of high platelet count and high hematocrit, by Marc Sorigue

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Obesity as a Causal Risk Factor for Aortic Valve Stenosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Lipoprotein(a) Reduction in Persons with Cardiovascular Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Hypertriglyceridemia prevalence is increasing as more individuals become obese, and chylomicronemia risk factors for the individual and community have not been described previously.

OBJECTIVE: To describe chylomicronemia risk factors in the general population for individuals and community.

METHODS: A total of 108 711 individuals from the Copenhagen General Population Study were grouped as unlikely chylomicronemia (nonfasting triglycerides <2 mmol L-1 (177 mg dL-1 )), possible chylomicronemia (2-4.99 mmol L-1 (177-442 mg dL-1 )), probable chylomicronemia (5-9.99 mmol L-1 (443-885 mg dL-1 )) and definite chylomicronemia (≥10 mmol L-1 (≥ 886 mg dL-1 )). Relative risk (RR) from Poisson regression ranked dichotomized chylomicronemia risk factors for individuals, and population attributable fractions (PAF) for the community: type 2 diabetes, alcohol intake, obesity, fat intake, hypothyroidism, kidney function, education, sedentary lifestyle, menopause and hormone replacement (women).

RESULTS: For women and men, chylomicronemia was unlikely in 81% and 64%, possible in 18% and 33%, probable in 1% and 3% and definite in 0.03% and 0.14%, respectively. For the individual, the three top-ranked risk factors for probable/definite versus unlikely chylomicronemia in women were type 2 diabetes (RR: 4.21; 95% confidence interval: 3.30-5.36), menopause (RR: 3.74; 2.62-5.36) and obesity (RR: 3.44; 2.81-4.21). Corresponding top-ranked risk factors in men were obesity (RR: 3.86; 3.46-4.30), type 2 diabetes (RR: 1.88; 1.61-2.19) and reduced kidney function (RR: 1.86; 1.48-2.34). For the community, top-ranked risk factors in women were menopause (PAF: 63%), obesity (PAF: 29%) and type 2 diabetes (PAF: 15%). Corresponding top-ranked risk factors in men were obesity (PAF: 29%), type 2 diabetes (PAF: 6.4%) and sedentary lifestyle (PAF: 6.0%).

CONCLUSIONS: Obesity and type 2 diabetes were the most important modifiable chylomicronemia risk factors in women and men, both for the individual and community. This could influence chylomicronemia prevention and help design randomized trials aimed at reducing triglycerides.

Original languageEnglish
JournalJournal of Internal Medicine
Volume283
Issue number4
Pages (from-to)392-404
Number of pages13
ISSN0954-6820
DOIs
Publication statusPublished - Apr 2018

ID: 56616315