Chronologic order of appearance of immune-mediated inflammatory diseases relative to diagnosis of psoriasis

Yuki M F Andersen; Jashin J Wu; Jacob P Thyssen; Alexander Egeberg

doi:10.1016/j.jaad.2019.04.033

Chronologic order of appearance of immune-mediated inflammatory diseases relative to diagnosis of psoriasis

Yuki M F Andersen, Jashin J Wu, Jacob P Thyssen, Alexander Egeberg

Dermatology and Allergy

Abstract

BACKGROUND: Psoriasis is a common inflammatory skin disease associated with several immune-mediated inflammatory diseases (IMIDs); however, little is known of the chronology of disease development.

OBJECTIVE: To investigate the chronology of IMIDs relative to psoriasis.

METHODS: We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n = 10,923) and general population controls (n = 109,230).

RESULTS: Approximately 20% of patients with psoriasis developed ≥1 IMID, with a 5-fold increased risk compared with the general population. Most IMIDs were diagnosed before psoriasis, except for psoriatic arthritis. Psoriasis was significantly associated with having multiple IMIDs (odds ratio 15.2, 95% confidence interval 11.6-20.0). Human leukocyte antigen B27 positivity was significantly more frequent among psoriasis patients.

LIMITATIONS: Clinical measurements were unavailable.

CONCLUSION: IMIDs occur frequently in patients with psoriasis and most are diagnosed before psoriasis. The observed chronology might represent important mechanisms of disease development.

Original language	English
Journal	Journal of the American Academy of Dermatology
Volume	81
Issue number	6
Pages (from-to)	1283-1291
Number of pages	9
ISSN	0190-9622
DOIs	https://doi.org/10.1016/j.jaad.2019.04.033
Publication status	Published - Dec 2019

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@article{d28286e9bd354ae7a0c9bb9dbc811a89,

title = "Chronologic order of appearance of immune-mediated inflammatory diseases relative to diagnosis of psoriasis",

abstract = "BACKGROUND: Psoriasis is a common inflammatory skin disease associated with several immune-mediated inflammatory diseases (IMIDs); however, little is known of the chronology of disease development.OBJECTIVE: To investigate the chronology of IMIDs relative to psoriasis.METHODS: We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n = 10,923) and general population controls (n = 109,230).RESULTS: Approximately 20% of patients with psoriasis developed ≥1 IMID, with a 5-fold increased risk compared with the general population. Most IMIDs were diagnosed before psoriasis, except for psoriatic arthritis. Psoriasis was significantly associated with having multiple IMIDs (odds ratio 15.2, 95% confidence interval 11.6-20.0). Human leukocyte antigen B27 positivity was significantly more frequent among psoriasis patients.LIMITATIONS: Clinical measurements were unavailable.CONCLUSION: IMIDs occur frequently in patients with psoriasis and most are diagnosed before psoriasis. The observed chronology might represent important mechanisms of disease development.",

author = "Andersen, {Yuki M F} and Wu, {Jashin J} and Thyssen, {Jacob P} and Alexander Egeberg",

year = "2019",

month = dec,

doi = "10.1016/j.jaad.2019.04.033",

language = "English",

volume = "81",

pages = "1283--1291",

journal = "Journal of the American Academy of Dermatology",

issn = "0190-9622",

publisher = "Mosby, Inc",

number = "6",

}

TY - JOUR

T1 - Chronologic order of appearance of immune-mediated inflammatory diseases relative to diagnosis of psoriasis

AU - Andersen, Yuki M F

AU - Wu, Jashin J

AU - Thyssen, Jacob P

AU - Egeberg, Alexander

PY - 2019/12

Y1 - 2019/12

N2 - BACKGROUND: Psoriasis is a common inflammatory skin disease associated with several immune-mediated inflammatory diseases (IMIDs); however, little is known of the chronology of disease development.OBJECTIVE: To investigate the chronology of IMIDs relative to psoriasis.METHODS: We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n = 10,923) and general population controls (n = 109,230).RESULTS: Approximately 20% of patients with psoriasis developed ≥1 IMID, with a 5-fold increased risk compared with the general population. Most IMIDs were diagnosed before psoriasis, except for psoriatic arthritis. Psoriasis was significantly associated with having multiple IMIDs (odds ratio 15.2, 95% confidence interval 11.6-20.0). Human leukocyte antigen B27 positivity was significantly more frequent among psoriasis patients.LIMITATIONS: Clinical measurements were unavailable.CONCLUSION: IMIDs occur frequently in patients with psoriasis and most are diagnosed before psoriasis. The observed chronology might represent important mechanisms of disease development.

AB - BACKGROUND: Psoriasis is a common inflammatory skin disease associated with several immune-mediated inflammatory diseases (IMIDs); however, little is known of the chronology of disease development.OBJECTIVE: To investigate the chronology of IMIDs relative to psoriasis.METHODS: We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n = 10,923) and general population controls (n = 109,230).RESULTS: Approximately 20% of patients with psoriasis developed ≥1 IMID, with a 5-fold increased risk compared with the general population. Most IMIDs were diagnosed before psoriasis, except for psoriatic arthritis. Psoriasis was significantly associated with having multiple IMIDs (odds ratio 15.2, 95% confidence interval 11.6-20.0). Human leukocyte antigen B27 positivity was significantly more frequent among psoriasis patients.LIMITATIONS: Clinical measurements were unavailable.CONCLUSION: IMIDs occur frequently in patients with psoriasis and most are diagnosed before psoriasis. The observed chronology might represent important mechanisms of disease development.

U2 - 10.1016/j.jaad.2019.04.033

DO - 10.1016/j.jaad.2019.04.033

M3 - Journal article

C2 - 31009673

SN - 0190-9622

VL - 81

SP - 1283

EP - 1291

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 6

ER -

Chronologic order of appearance of immune-mediated inflammatory diseases relative to diagnosis of psoriasis

Abstract

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