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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Chronic obstructive pulmonary disease and risk of infection

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  1. Chronic care for COPD patients in Denmark

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  2. Histamine release after nasal challenge with anti-IgE and Staphylococcus aureus in patients with allergic rhinitis

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  1. The long-lasting dark shadow of past and present smoking

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  2. β2-Adrenergic genotypes and risk of severe exacerbations in COPD: a prospective cohort study

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  3. Tau-protein concentrations are not elevated in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy

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  4. Midlife cardiorespiratory fitness and the long-term risk of chronic obstructive pulmonary disease

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  5. Misinterpretation of time-to-first event curves can lead to inappropriate treatment

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This review article focuses on the risk of infections in patients with chronic obstructive pulmonary disease (COPD). Throughout the years there have been a number of studies describing the risk of pulmonary infections in patients with COPD, whereas only few studies have focused on the risk of infection outside the lungs. With increasing severity of COPD the risk of respiratory tract infection also increases. The impairment of the innate immune system is most likely responsible for both the colonization of respiratory tract with bacteria and for an increased risk of infection with new strains of bacteria causing acute exacerbations. Also lung infections like pneumonia, lung abscess and empyema are more often seen in patients with COPD than in healthy subjects. With regard to extrapulmonary infections, it seems that COPD patients are not at higher risk of infection compared with subjects without COPD. It is concluded that COPD is significantly associated with an increased risk of various respiratory tract infections, but not with infections outside the respiratory system.
Original languageEnglish
JournalPneumonologia i Alergologia Polska
Volume77
Issue number3
Pages (from-to)284-8
Number of pages4
ISSN0867-7077
Publication statusPublished - 2009

    Research areas

  • Anti-Bacterial Agents, Causality, Comorbidity, Disease Progression, Europe, Humans, Prognosis, Pulmonary Disease, Chronic Obstructive, Respiratory Tract Infections, Risk Factors, World Health

ID: 32576493