Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Chronic Non-bacterial Osteomyelitis: A Review

Research output: Contribution to journalReviewResearchpeer-review

  1. Multiple Fractures and Impaired Bone Fracture Healing in a Patient with Pycnodysostosis and Hypophosphatasia

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Bone mass development in childhood and its association with physical activity and vitamin D levels. The CHAMPS-Study DK

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. The age-specific incidence of type 2 diabetes in Danish elderly adults – the role of size at birth

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  2. Denosumab vs. zoledronic acid treatment in post-menopausal breast cancer: a 2-year prospective observational study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Republished: Severe hypophosphataemia following oral bisphosphonate treatment in a patient with osteoporosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Does vascular endothelial dysfunction play a role in physical frailty and sarcopenia? A systematic review

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

Chronic non-bacterial osteomyelitis (CNO) is a rare auto-inflammatory bone disorder, with a prevalence of around one in a million patients. In the more severe form, it is referred to as chronic recurrent multifocal osteomyelitis (CRMO). We present the current knowledge on epidemiology, pathophysiology as well as diagnostic options and treatment regimens. CNO/CRMO most commonly affects children and lesions are often seen in the metaphyseal plates of the long bones, but cases have been described affecting all age groups as well as lesions in almost every bone. It is, therefore, a disease that clinicians can encounter in many different settings. Diagnosis is mainly a matter of exclusion from differential diagnoses such as bacterial osteomyelitis and cancer. Magnetic resonance imaging is the best radiological method for diagnosis coupled with a low-grade inflammation and a history of recurring episodes. Treatment is based on case reports and consists of alleviating symptoms with non-steroidal anti-inflammatory drugs since the disease is often self-limiting. Recently, more active treatments using either bisphosphonates or biological treatment are becoming more common, to prevent long term bone damage. In general, due to its rarity, much remains unclear regarding CNO/CRMO. We review the known literature on CNO/CRMO and propose areas of interest as well as possible ways to make current diagnostic criteria more detailed. We also find unifocal cases of the jaw to be a possible sub-type that may need its own set of criteria.

Original languageEnglish
JournalCalcified Tissue International
Volume104
Issue number5
Pages (from-to)544-553
ISSN0171-967X
DOIs
Publication statusPublished - May 2019

    Research areas

  • Autoinflammatory bone disorder, Pustulotic arthro-osteitis, Rare bone diseases, Sclerosing osteitis

ID: 56463114