Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Chronic migraine--classification, characteristics and treatment

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Calcitonin gene-related peptide - beyond migraine prophylaxis

    Research output: Contribution to journalComment/debateResearchpeer-review

  2. Ageing as a risk factor for neurodegenerative disease

    Research output: Contribution to journalReviewResearchpeer-review

  3. Post-traumatic headache: epidemiology and pathophysiological insights

    Research output: Contribution to journalReviewResearchpeer-review

  4. Does inflammation have a role in migraine?

    Research output: Contribution to journalReviewResearchpeer-review

  5. CGRP as the target of new migraine therapies - successful translation from bench to clinic

    Research output: Contribution to journalReviewResearchpeer-review

  1. Von Frey testing revisited - provision of an online algorithm for improved accuracy of 50% thresholds

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. ICHD-3 is significantly more specific than ICHD-3 beta for diagnosis of migraine with aura and with typical aura

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. PACAP27 induces migraine-like attacks in migraine patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Reply: Hyperpolarization through ATP-sensitive potassium channels; relevance to migraine pathology

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Hans-Christoph Diener
  • David W Dodick
  • Peter J Goadsby
  • Richard B Lipton
  • Jes Olesen
  • Stephen D Silberstein
View graph of relations
According to the revised 2nd Edition of the International Classification of Headache Disorders, primary headaches can be categorized as chronic or episodic; chronic migraine is defined as headaches in the absence of medication overuse, occurring on ≥15 days per month for ≥3 months, of which headaches on ≥8 days must fulfill the criteria for migraine without aura. Prevalence and incidence data for chronic migraine are still uncertain, owing to the heterogeneous definitions used to identify the condition in population-based studies over the past two decades. Chronic migraine is severely disabling and difficult to manage, as affected patients experience substantially more-frequent headaches, comorbid pain and affective disorders, and fewer pain-free intervals, than do those with episodic migraine. Data on the treatment of chronic migraine are scarce because most migraine-prevention trials excluded patients who had headaches for ≥15 days per month. Despite this lack of reliable data, a wealth of expert opinion and a few evidence-based treatment options are available for managing chronic migraine. Trial data are available for topiramate and botulinum toxin type A, and expert opinion suggests that conventional preventive therapy for episodic migraine may also be useful. This Review discusses the evolution of our understanding of chronic migraine, including its epidemiology, pathophysiology, clinical characteristics and treatment options.
Original languageEnglish
JournalNature Reviews. Neurology
Volume8
Issue number3
Pages (from-to)162-71
Number of pages10
ISSN1759-4758
DOIs
Publication statusPublished - 2012

ID: 35944742