Chronic kidney disease in patients with the Philadelphia-negative chronic myeloproliferative neoplasms
Research output: Contribution to journal › Journal article › Research › peer-review
BACKGROUND: The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality.
METHODS: This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years.
RESULTS: 29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3mL/min/1.73m(2)) and eGFR was negatively correlated to monocyte and neutrophil counts.
CONCLUSION: Kidney impairment might contribute to the increased mortality observed in MPN patients.
| Translated title of the contribution | Kronisk nyresygdom i patienter med Philidelphia-negative kroniske myeloproliferative neoplasmer |
|---|---|
| Original language | English |
| Journal | Leukemia Research |
| Volume | 38 |
| Issue number | 4 |
| Pages (from-to) | 490-5 |
| Number of pages | 6 |
| ISSN | 0145-2126 |
| DOIs | |
| Publication status | Published - Apr 2014 |
- Aged, Aged, 80 and over, Disease Progression, Female, Glomerular Filtration Rate, Humans, Incidence, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative/complications, Longitudinal Studies, Male, Middle Aged, Renal Insufficiency, Chronic/complications, Retrospective Studies
Research areas
ID: 55097195