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Chronic kidney disease in patients with the Philadelphia-negative chronic myeloproliferative neoplasms

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Birth weight in offspring and leukaemia risk in parents-A nation-wide register-based cohort study from Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

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BACKGROUND: The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality.

METHODS: This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years.

RESULTS: 29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3mL/min/1.73m(2)) and eGFR was negatively correlated to monocyte and neutrophil counts.

CONCLUSION: Kidney impairment might contribute to the increased mortality observed in MPN patients.

Translated title of the contributionKronisk nyresygdom i patienter med Philidelphia-negative kroniske myeloproliferative neoplasmer
Original languageEnglish
JournalLeukemia Research
Volume38
Issue number4
Pages (from-to)490-5
Number of pages6
ISSN0145-2126
DOIs
Publication statusPublished - Apr 2014

    Research areas

  • Aged, Aged, 80 and over, Disease Progression, Female, Glomerular Filtration Rate, Humans, Incidence, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative/complications, Longitudinal Studies, Male, Middle Aged, Renal Insufficiency, Chronic/complications, Retrospective Studies

ID: 55097195