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Chromosome errors in human eggs shape natural fertility over reproductive life span

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Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.

Original languageEnglish
JournalScience
Volume365
Issue number6460
Pages (from-to)1466-1469
Number of pages4
ISSN0036-8075
DOIs
Publication statusPublished - 27 Sep 2019

ID: 58634428