Abstract
Membrane vesicles were isolated from one beta-lactam-sensitive and three beta-lactam-resistant Pseudomonas aeruginosa clinical isolates from patients with cystic fibrosis. The presence of the chromosomally encoded beta-lactamase in the membrane vesicles was shown by electron microscopy and enzymatic studies. This is the first report of extracellular secretion of beta-lactamase in P. aeruginosa and it seems that the enzyme is packaged into membrane vesicles.
| Original language | English |
|---|---|
| Journal | The Journal of antimicrobial chemotherapy |
| Volume | 45 |
| Issue number | 1 |
| Pages (from-to) | 9-13 |
| Number of pages | 5 |
| ISSN | 0305-7453 |
| DOIs | |
| Publication status | Published - Jan 2000 |
| Externally published | Yes |
Keywords
- Cell Membrane/enzymology
- Chromosomes, Bacterial/genetics
- Cystic Fibrosis/microbiology
- Humans
- Lung/microbiology
- Pseudomonas aeruginosa/enzymology
- beta-Lactam Resistance
- beta-Lactamases/genetics
Fingerprint
Dive into the research topics of 'Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS