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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Chromosomal Abnormalities in Offspring of Young Cancer Survivors: A Population-Based Cohort Study in Denmark

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  • Betina Frydenlund Nielsen
  • Anne Aarslev Schmidt
  • John J Mulvihill
  • Kirsten Frederiksen
  • E Janet Tawn
  • Marilyn Stovall
  • Christoffer Johansen
  • John D Boice
  • Jeanette Falck Winther
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To examine whether cancer survivors diagnosed before age 35 years are more likely to have offspring with chromosomal abnormalities than their siblings, chromosomal abnormalities were determined in a population-based cohort of 14 611 offspring (14 580 live-born children and 31 fetuses) of 8945 Danish cancer survivors and 40 859 offspring (40 794 live-born children and 65 fetuses) of 19 536 siblings. Chromosomal abnormalities include numeric and structural abnormalities. Odds ratios were estimated by multiple logistic regression models comparing the risk of chromosomal abnormalities among survivors' offspring with that in siblings' offspring. In a subgroup of survivors with gonadal radiation doses (mean = 0.95 Gy for males and 0.91 Gy for females), no indication of a dose response was found. Overall, no increased risk of chromosomal abnormalities among survivors' offspring was observed compared with their siblings' offspring (odds ratio = 0.99, 95% confidence interval = 0.67 to 1.44, two-sided P = .94), with similar risk between male and female survivors. Cancer survivors were not more likely than their siblings to have children with a chromosomal abnormality.

Original languageEnglish
JournalNational Cancer Institute. Journal (Online)
Volume110
Issue number5
Pages (from-to)534-538
ISSN1460-2105
DOIs
Publication statusPublished - 2018
Externally publishedYes

    Research areas

  • Journal Article

ID: 52146209