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Chromatographic comparison of bupivacaine imprinted polymers prepared in crushed monolith, microsphere, silica-based composite and capillary monolith formats

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Harvard

Oxelbark, J, Legido-Quigley, C, Aureliano, CSA, Titirici, M-M, Schillinger, E, Sellergren, B, Courtois, J, Irgum, K, Dambies, L, Cormack, PAG, Sherrington, DC & De Lorenzi, E 2007, 'Chromatographic comparison of bupivacaine imprinted polymers prepared in crushed monolith, microsphere, silica-based composite and capillary monolith formats' Journal of Chromatography, vol. 1160, no. 1-2, pp. 215-26. https://doi.org/10.1016/j.chroma.2007.05.057

APA

CBE

Oxelbark J, Legido-Quigley C, Aureliano CSA, Titirici M-M, Schillinger E, Sellergren B, Courtois J, Irgum K, Dambies L, Cormack PAG, Sherrington DC, De Lorenzi E. 2007. Chromatographic comparison of bupivacaine imprinted polymers prepared in crushed monolith, microsphere, silica-based composite and capillary monolith formats. Journal of Chromatography. 1160(1-2):215-26. https://doi.org/10.1016/j.chroma.2007.05.057

MLA

Vancouver

Author

Oxelbark, Joakim ; Legido-Quigley, Cristina ; Aureliano, Carla S A ; Titirici, Maria-Magdalena ; Schillinger, Eric ; Sellergren, Börje ; Courtois, Julien ; Irgum, Knut ; Dambies, Laurent ; Cormack, Peter A G ; Sherrington, David C ; De Lorenzi, Ersilia. / Chromatographic comparison of bupivacaine imprinted polymers prepared in crushed monolith, microsphere, silica-based composite and capillary monolith formats. In: Journal of Chromatography. 2007 ; Vol. 1160, No. 1-2. pp. 215-26.

Bibtex

@article{cb56e0e16a414a03897c6daa1d405180,
title = "Chromatographic comparison of bupivacaine imprinted polymers prepared in crushed monolith, microsphere, silica-based composite and capillary monolith formats",
abstract = "A comprehensive comparison of five chromatographic stationary phases based on molecularly imprinted polymers is presented. Efficiency, imprinting factors, water compatibility and batch-to-batch reproducibility are discussed for crushed monolith, microspheres, two silica-based composites and capillary monoliths, all imprinted with the local anaesthetic bupivacaine. Synthesis protocol and chromatographic test conditions have been kept fixed within certain limits, in order to provide further insight into the strengths and weaknesses of the different formats. Excluding microparticles, all formats give satisfactory performance, especially in aqueous mobile phases. An assessment of batch-to-batch reproducibility in different mobile phases adds further value to this comparison study.",
keywords = "Adsorption, Bupivacaine/chemistry, Chromatography, Liquid/methods, Microspheres, Polymers/chemical synthesis, Porosity, Silicon Dioxide/chemistry",
author = "Joakim Oxelbark and Cristina Legido-Quigley and Aureliano, {Carla S A} and Maria-Magdalena Titirici and Eric Schillinger and B{\"o}rje Sellergren and Julien Courtois and Knut Irgum and Laurent Dambies and Cormack, {Peter A G} and Sherrington, {David C} and {De Lorenzi}, Ersilia",
year = "2007",
month = "8",
day = "10",
doi = "10.1016/j.chroma.2007.05.057",
language = "English",
volume = "1160",
pages = "215--26",
journal = "Journal of Chromatography",
issn = "0021-9673",
publisher = "Elsevier BV",
number = "1-2",

}

RIS

TY - JOUR

T1 - Chromatographic comparison of bupivacaine imprinted polymers prepared in crushed monolith, microsphere, silica-based composite and capillary monolith formats

AU - Oxelbark, Joakim

AU - Legido-Quigley, Cristina

AU - Aureliano, Carla S A

AU - Titirici, Maria-Magdalena

AU - Schillinger, Eric

AU - Sellergren, Börje

AU - Courtois, Julien

AU - Irgum, Knut

AU - Dambies, Laurent

AU - Cormack, Peter A G

AU - Sherrington, David C

AU - De Lorenzi, Ersilia

PY - 2007/8/10

Y1 - 2007/8/10

N2 - A comprehensive comparison of five chromatographic stationary phases based on molecularly imprinted polymers is presented. Efficiency, imprinting factors, water compatibility and batch-to-batch reproducibility are discussed for crushed monolith, microspheres, two silica-based composites and capillary monoliths, all imprinted with the local anaesthetic bupivacaine. Synthesis protocol and chromatographic test conditions have been kept fixed within certain limits, in order to provide further insight into the strengths and weaknesses of the different formats. Excluding microparticles, all formats give satisfactory performance, especially in aqueous mobile phases. An assessment of batch-to-batch reproducibility in different mobile phases adds further value to this comparison study.

AB - A comprehensive comparison of five chromatographic stationary phases based on molecularly imprinted polymers is presented. Efficiency, imprinting factors, water compatibility and batch-to-batch reproducibility are discussed for crushed monolith, microspheres, two silica-based composites and capillary monoliths, all imprinted with the local anaesthetic bupivacaine. Synthesis protocol and chromatographic test conditions have been kept fixed within certain limits, in order to provide further insight into the strengths and weaknesses of the different formats. Excluding microparticles, all formats give satisfactory performance, especially in aqueous mobile phases. An assessment of batch-to-batch reproducibility in different mobile phases adds further value to this comparison study.

KW - Adsorption

KW - Bupivacaine/chemistry

KW - Chromatography, Liquid/methods

KW - Microspheres

KW - Polymers/chemical synthesis

KW - Porosity

KW - Silicon Dioxide/chemistry

U2 - 10.1016/j.chroma.2007.05.057

DO - 10.1016/j.chroma.2007.05.057

M3 - Journal article

VL - 1160

SP - 215

EP - 226

JO - Journal of Chromatography

JF - Journal of Chromatography

SN - 0021-9673

IS - 1-2

ER -

ID: 54962812