Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Cholecystokinin and the hormone concept

Research output: Contribution to journalReviewpeer-review

DOI

  1. Determining minimal important change for the thyroid-related quality of life questionnaire ThyPRO

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Free testosterone and cardiometabolic parameters in men: comparison of algorithms

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The economic impact of prevention, monitoring and treatment strategies for iodine deficiency disorders in Germany

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy young men

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Expression of cholecystokinin and its receptors in the intestinal tract of type 2 diabetes patients and healthy controls

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Gastrin and the moderate hypergastrinemias

    Research output: Contribution to journalReviewpeer-review

  4. On premises and principles for measurement of gastrointestinal peptide hormones

    Research output: Contribution to journalReviewpeer-review

View graph of relations

The birth certificate for endocrinology was Bayliss' and Starling's demonstration in 1902 that regulation of bodily functions is not only neuronal but also due to blood-borne messengers. Starling named these messengers hormones. Since then transport via blood has defined hormones. This definition, however, may be too narrow. Thus, today we know that several peptide hormones are not only produced and released to blood from endocrine cells but also released from neurons, myocytes, immune cells, endothelial cells, spermatogenic cells, fat cells, etc. And they are often secreted in cell-specific molecular forms with more or less different spectra of activity. The present review depicts this development with the story about cholecystokinin which was discovered in 1928 as a hormone and still in 1976 was conceived as a single blood-borne peptide. Today's multifaceted picture of cholecystokinin suggests that time may be ripe for expansion of the hormone concept to all messenger molecules, which activate their target cells - irrespective of their road to the target (endocrine, neurocrine, neuronal, paracrine, autocrine, etc.) and irrespective of their kind of activity as classical hormone, growth factor, neurotransmitter, adipokine, cytokine, myokine, or fertility factor.

Original languageEnglish
JournalEndocrine Connections
Volume10
Issue number3
Pages (from-to)R139-R150
ISSN2049-3614
DOIs
Publication statusPublished - Mar 2021

    Research areas

  • Bioactive peptides, Cholecystokinin, Growth factors, Hormone concept, Neurotransmitter peptides

ID: 64827707