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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Chimeric antigen receptor-T-cellebehandling

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  1. Natarbejde og komplikationer i graviditeten

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  2. Discontinuation of antidepressants

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  3. Donorsøgning til Hæmatopoietisk stamcelle transplantation

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  4. Kan prævention udløse depression?

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  5. Somatiske årsager til akut opståede psykiatriske tilstande hos børn og unge

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  1. Citrulline as a biomarker of bacteraemia during induction treatment for childhood acute lymphoblastic leukaemia

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  2. Changes in the Tumor Immune Microenvironment during Disease Progression in Patients with Ovarian Cancer

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  3. KEYNOTE-022 part 3: a randomized, double-blind, phase 2 study of pembrolizumab, dabrafenib, and trametinib in BRAF-mutant melanoma

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Although treatment of haematological cancer has improved significantly during the latest decades, the prognosis is poor in case of relapse or refractory disease. This review describes the chimeric antigen receptor (CAR) T-cell therapy, which has emerged as a new promising treatment principle, in which the patient's own T-cells are genetically modified to recognise cancer cells. The possible side effects are usually only transient. A commercial CD19 CAR T-cell product has recently been approved as treatment for acute lympho-blastic leukaemia in children and young adults in Denmark, and a non-commercial CAR T-cell production is being established.

Original languageEnglish
JournalUgeskrift for Laeger
Volume181
Issue number20A
ISSN0041-5782
Publication statusPublished - 14 Oct 2019

ID: 58521171