Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Children sustain high levels of skin DNA photodamage, with a modest increase of serum 25-hydroxyvitamin D3 , after a summer holiday in Northern Europe

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Comparing apples, oranges and atopic dermatitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Characteristics and prevalence of plaque psoriasis in patients with palmoplantar pustulosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Are demodex mites the best target for rosacea treatments?

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Seborrhoeic dermatitis - understood or understudied?

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. A novel LC-MS/MS method to quantify eumelanin and pheomelanin and their relation to UVR sensitivity - A study on human skin biopsies

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Daylight photodynamic therapy of actinic keratosis without curettage is as effective as with curettage: a randomized clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Daylight PDT acts by continuous activation of PpIX

    Research output: Contribution to journalEditorialResearchpeer-review

  5. Serum 25(OH)D levels after oral vitamin D3 supplementation and UVB exposure correlate

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Childhood solar ultraviolet radiation (UVR) exposure increases the risk of skin cancer in adulthood, which is associated with mutations caused by UVR-induced cyclobutane pyrimidine dimers (CPD). Solar UVR is also the main source of vitamin D, essential for healthy bone development in children.

OBJECTIVES: To assess the impact of a 12-day Baltic Sea (54° N) beach holiday on serum 25-hydroxyvitamin D3 [25(OH)D3 ] and CPD in 32 healthy Polish children (skin types I-IV).

METHODS: Blood and urine were collected before and after the holiday and assessed for 25(OH)D3 and excreted CPD, respectively, and personal UVR exposure was measured. Diaries were used to record sunbathing, sunburn and sunscreen use. Before- and after-holiday skin redness and pigmentation were measured by reflectance spectroscopy.

RESULTS: The average ± SD daily exposure UVR dose was 2·4 ± 1·5 standard erythema doses (SEDs), which is borderline erythemal. The mean concentration of 25(OH)D3 increased (× 1·24 ± 0·19) from 64·7 ± 13·3 to 79·3 ± 18·7 nmol L-1 (P < 0·001). Mean CPD increased 12·6 ± 10·0-fold from 26·9 ± 17·9 to 248·9 ± 113·4 fmol μmol-1 creatinine (P < 0·001). Increased 25(OH)D3 was accompanied by a very much greater increase in DNA damage associated with carcinogenic potential. Overall, skin type had no significant effects on behavioural, clinical or analytical outcomes, but skin types I/II had more CPD (unadjusted P = 0·0496) than skin types III/IV at the end of the holiday.

CONCLUSIONS: Careful consideration must be given to the health outcomes of childhood solar exposure, and a much better understanding of the risk-benefit relationships of such exposure is required. Rigorous photoprotection is necessary for children, even in Northern Europe.

Original languageEnglish
JournalBritish Journal of Dermatology
Volume179
Issue number4
Pages (from-to)940-950
Number of pages11
ISSN0007-0963
DOIs
Publication statusPublished - Oct 2018

ID: 56141159