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Children exposed or unexposed to HIV: weight, height and BMI during the first five years of life. A Danish Nationwide Cohort Study

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@article{77bd58ac7fdc497382a474754ce4fb99,
title = "Children exposed or unexposed to HIV: weight, height and BMI during the first five years of life. A Danish Nationwide Cohort Study",
abstract = "BACKGROUND: Exposures to HIV and antiretroviral therapy in utero may have adverse effects on infant growth. We aimed to compare anthropometric outcomes of HIV exposed uninfected (HEU) children born in Denmark aged 0-5 years to children not exposed to HIV.METHODS: In a nationwide register-based study we included all singleton HEU children born in Denmark, 2000-2016. HEU children were individually matched by child sex, parity and maternal country of birth to five singleton controls born to HIV uninfected mothers. Weight-for-age (WAZ), Length-for-age (LAZ) and Weight-for-Length (WLZ)/BMI-for-age (BMI) z-scores were generated according to the WHO standards and the Fenton growth chart for premature infants. Differences in WAZ, LAZ and BMI z-scores were analyzed using linear mixed models, both univariate and adjusted for social and maternal factors.RESULTS: In total, 485 HEU children and 2.495 controls were included. Compared to controls, HEU children were smaller at birth with an adjusted difference in mean WAZ and LAZ scores of -0.29 (95{\%}CI -0.46:-0.12: p=<0.001) and -0.51 (95{\%}CI -0.71:-0.31: p=<0.001), respectively. Over time, there was a trend towards increasing WAZ and LAZ in HEU children, and there was no significant difference in adjusted WAZ z-scores after age 14 days (-0.13 (95{\%} CI -0.27:0.01: p=0.07) and LAZ z-scores after age 6 months (-0.15 (95{\%}CI -0.32:0.02: p=0.08).CONCLUSION: Compared to a matched control group, HEU children were smaller at birth, but this difference decreased with time and is not considered to have a negative impact on the health and well-being of HEU children during early childhood.",
author = "Ellen Moseholm and Marie Helleberg and H{\aa}kon Sandholdt and Katzenstein, {Terese L} and Merete Storgaard and Gitte Pedersen and Johansen, {Isik S} and Nina Weis",
note = "{\circledC} The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2020",
month = "5",
doi = "10.1093/cid/ciz605",
language = "English",
volume = "70",
pages = "2169--2177",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "University of Chicago Press",
number = "10",

}

RIS

TY - JOUR

T1 - Children exposed or unexposed to HIV

T2 - weight, height and BMI during the first five years of life. A Danish Nationwide Cohort Study

AU - Moseholm, Ellen

AU - Helleberg, Marie

AU - Sandholdt, Håkon

AU - Katzenstein, Terese L

AU - Storgaard, Merete

AU - Pedersen, Gitte

AU - Johansen, Isik S

AU - Weis, Nina

N1 - © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2020/5

Y1 - 2020/5

N2 - BACKGROUND: Exposures to HIV and antiretroviral therapy in utero may have adverse effects on infant growth. We aimed to compare anthropometric outcomes of HIV exposed uninfected (HEU) children born in Denmark aged 0-5 years to children not exposed to HIV.METHODS: In a nationwide register-based study we included all singleton HEU children born in Denmark, 2000-2016. HEU children were individually matched by child sex, parity and maternal country of birth to five singleton controls born to HIV uninfected mothers. Weight-for-age (WAZ), Length-for-age (LAZ) and Weight-for-Length (WLZ)/BMI-for-age (BMI) z-scores were generated according to the WHO standards and the Fenton growth chart for premature infants. Differences in WAZ, LAZ and BMI z-scores were analyzed using linear mixed models, both univariate and adjusted for social and maternal factors.RESULTS: In total, 485 HEU children and 2.495 controls were included. Compared to controls, HEU children were smaller at birth with an adjusted difference in mean WAZ and LAZ scores of -0.29 (95%CI -0.46:-0.12: p=<0.001) and -0.51 (95%CI -0.71:-0.31: p=<0.001), respectively. Over time, there was a trend towards increasing WAZ and LAZ in HEU children, and there was no significant difference in adjusted WAZ z-scores after age 14 days (-0.13 (95% CI -0.27:0.01: p=0.07) and LAZ z-scores after age 6 months (-0.15 (95%CI -0.32:0.02: p=0.08).CONCLUSION: Compared to a matched control group, HEU children were smaller at birth, but this difference decreased with time and is not considered to have a negative impact on the health and well-being of HEU children during early childhood.

AB - BACKGROUND: Exposures to HIV and antiretroviral therapy in utero may have adverse effects on infant growth. We aimed to compare anthropometric outcomes of HIV exposed uninfected (HEU) children born in Denmark aged 0-5 years to children not exposed to HIV.METHODS: In a nationwide register-based study we included all singleton HEU children born in Denmark, 2000-2016. HEU children were individually matched by child sex, parity and maternal country of birth to five singleton controls born to HIV uninfected mothers. Weight-for-age (WAZ), Length-for-age (LAZ) and Weight-for-Length (WLZ)/BMI-for-age (BMI) z-scores were generated according to the WHO standards and the Fenton growth chart for premature infants. Differences in WAZ, LAZ and BMI z-scores were analyzed using linear mixed models, both univariate and adjusted for social and maternal factors.RESULTS: In total, 485 HEU children and 2.495 controls were included. Compared to controls, HEU children were smaller at birth with an adjusted difference in mean WAZ and LAZ scores of -0.29 (95%CI -0.46:-0.12: p=<0.001) and -0.51 (95%CI -0.71:-0.31: p=<0.001), respectively. Over time, there was a trend towards increasing WAZ and LAZ in HEU children, and there was no significant difference in adjusted WAZ z-scores after age 14 days (-0.13 (95% CI -0.27:0.01: p=0.07) and LAZ z-scores after age 6 months (-0.15 (95%CI -0.32:0.02: p=0.08).CONCLUSION: Compared to a matched control group, HEU children were smaller at birth, but this difference decreased with time and is not considered to have a negative impact on the health and well-being of HEU children during early childhood.

U2 - 10.1093/cid/ciz605

DO - 10.1093/cid/ciz605

M3 - Journal article

VL - 70

SP - 2169

EP - 2177

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 10

ER -

ID: 57520758