TY - JOUR
T1 - Childhood trauma in children at familial high risk of schizophrenia or bipolar disorder
T2 - A longitudinal study. The Danish High Risk and Resilience Study - VIA 7 and VIA 11
AU - Brandt, Julie Marie
AU - Hemager, Nicoline
AU - Gregersen, Maja
AU - Søndergaard, Anne
AU - Falkenberg Krantz, Mette
AU - Ohland, Jessica
AU - Wilms, Martin
AU - Birkehøj Rohd, Sinnika
AU - Hjorthøj, Carsten
AU - Veddum, Lotte
AU - Bruun Knudsen, Christina
AU - Krogh Andreassen, Anna
AU - Greve, Aja
AU - Spang, Katrine Søborg
AU - Christiani, Camilla Austa
AU - Ellersgaard, Ditte
AU - Klee Burton, Birgitte
AU - Gantriis, Ditte Lou
AU - Bliksted, Vibeke
AU - Mors, Ole
AU - Plessen, Kerstin Jessica
AU - Møllegaard Jepsen, Jens Richardt
AU - Nordentoft, Merete
AU - Elgaard Thorup, Anne Amalie
N1 - © 2022 The British Psychological Society.
PY - 2022/11/1
Y1 - 2022/11/1
N2 - OBJECTIVES: Childhood trauma increases the risk of developing mental illness as does being born to parents with schizophrenia or bipolar disorder. We aimed to compare prevalence of lifetime childhood trauma among 11-year-old children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) compared with population-based controls (PBCs).DESIGN: The study is a longitudinal, prospective cohort study of children at FHR-SZ, FHR-BP, and PBCs.METHODS: A cohort of 512 children at FHR-SZ (N = 199), FHR-BP (N = 118), and PBCs (N = 195) were examined at baseline (mean age 7.8, SD 0.2) and 451 children at FHR-SZ (N = 172), FHR-BP (N = 104), and PBCs (N = 175) were examined at four-year follow-up (mean age 11.9, SD 0.2, retention rate 87.3%). Childhood trauma was measured with a semi-structured interview.RESULTS: Children at FHR-BP had an elevated risk of exposure to any lifetime trauma (age 0-11 years) compared with PBCs (OR 2.082, 95%CI 1.223-3.545, p = .007) measured with binary logistic regression. One-way ANOVA revealed that both FHR-groups had a higher lifetime prevalence of exposure to a greater number of types of trauma compared with PBCs (FHR-SZ: observed mean: 1.53, 95%CI 1.29-1.77; FHR-BP: observed mean: 1.56, 95%CI 1.26-1.85; PBCs: observed mean: 0.99, 95%CI 0.82-1.17; p < .001). Binary logistic regression showed that the lifetime risk of exposure to interpersonal trauma (age 0-11 years) was elevated for both FHR-groups (FHR-SZ: OR 3.773, 95%CI 2.122-6.710, p < .001; FHR-BP: OR 3.602, 95%CI 1.913-6.783, p < .001).CONCLUSIONS: Children at FHR-SZ and FHR-BP are at increased risk for being exposed to childhood trauma compared with PBCs. This study underscores the need for early detection, support, and prevention of childhood trauma in children at FHR-SZ and FHR-BP.
AB - OBJECTIVES: Childhood trauma increases the risk of developing mental illness as does being born to parents with schizophrenia or bipolar disorder. We aimed to compare prevalence of lifetime childhood trauma among 11-year-old children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) compared with population-based controls (PBCs).DESIGN: The study is a longitudinal, prospective cohort study of children at FHR-SZ, FHR-BP, and PBCs.METHODS: A cohort of 512 children at FHR-SZ (N = 199), FHR-BP (N = 118), and PBCs (N = 195) were examined at baseline (mean age 7.8, SD 0.2) and 451 children at FHR-SZ (N = 172), FHR-BP (N = 104), and PBCs (N = 175) were examined at four-year follow-up (mean age 11.9, SD 0.2, retention rate 87.3%). Childhood trauma was measured with a semi-structured interview.RESULTS: Children at FHR-BP had an elevated risk of exposure to any lifetime trauma (age 0-11 years) compared with PBCs (OR 2.082, 95%CI 1.223-3.545, p = .007) measured with binary logistic regression. One-way ANOVA revealed that both FHR-groups had a higher lifetime prevalence of exposure to a greater number of types of trauma compared with PBCs (FHR-SZ: observed mean: 1.53, 95%CI 1.29-1.77; FHR-BP: observed mean: 1.56, 95%CI 1.26-1.85; PBCs: observed mean: 0.99, 95%CI 0.82-1.17; p < .001). Binary logistic regression showed that the lifetime risk of exposure to interpersonal trauma (age 0-11 years) was elevated for both FHR-groups (FHR-SZ: OR 3.773, 95%CI 2.122-6.710, p < .001; FHR-BP: OR 3.602, 95%CI 1.913-6.783, p < .001).CONCLUSIONS: Children at FHR-SZ and FHR-BP are at increased risk for being exposed to childhood trauma compared with PBCs. This study underscores the need for early detection, support, and prevention of childhood trauma in children at FHR-SZ and FHR-BP.
KW - Adverse Childhood Experiences
KW - Bipolar Disorder/epidemiology
KW - Child
KW - Child, Preschool
KW - Denmark/epidemiology
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Longitudinal Studies
KW - Prospective Studies
KW - Schizophrenia/diagnosis
UR - http://www.scopus.com/inward/record.url?scp=85127131148&partnerID=8YFLogxK
U2 - 10.1111/bjc.12364
DO - 10.1111/bjc.12364
M3 - Journal article
C2 - 35332530
SN - 0144-6657
VL - 61
SP - 875
EP - 894
JO - In Session - Psychotherapy in Practice
JF - In Session - Psychotherapy in Practice
IS - 4
ER -