Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Childhood dyspraxia predicts adult-onset nonaffective-psychosis-spectrum disorder

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Age at Onset and Age at Treatment of Alcohol Use Disorders: Associations with Educational Level and Intelligence

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. A Nationwide Cohort Study of Nonrandom Mating in Schizophrenia and Bipolar Disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Longitudinal associations of self-reported satisfaction with life and vitality with risk of mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Stress management versus cognitive restructuring in trauma-affected refugees - A follow-up study on a pragmatic randomised trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Lifetime psychiatric hospital diagnoses among 8,412 Danish men registered in an outpatient alcohol clinic

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective-psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10-13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective-psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, χ2 (4, 244) = 18.61, p < .001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective-psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective-psychosis-spectrum disorders.

Original languageEnglish
JournalDevelopment and Psychopathology
Volume27
Issue number4 Pt 1
Pages (from-to)1323-30
Number of pages8
ISSN0954-5794
DOIs
Publication statusPublished - Nov 2015

ID: 46196464