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Chest x-ray findings in tuberculosis patients identified by passive and active case finding: A retrospective study

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@article{ac99eeb8bc3a4236a553f68ac555036b,
title = "Chest x-ray findings in tuberculosis patients identified by passive and active case finding: A retrospective study",
abstract = "Background: Chest x-ray is central in screening and diagnosis of tuberculosis. However, sputum culture remains gold standard for diagnosis.Aim: To establish the rate of normal chest x-rays in tuberculosis patients found by spot sputum culture screening, and compare them to a group identified through passive case finding.Method: Chest x-rays from 39 culture-positive patients, identified by spot sputum culture screening in Copenhagen from 2012 to 2014, were included in the study (spot sputum culture group(SSC)). 39 normal chest x-rays from persons screened by mobile x-ray, and 39 chest x-rays from tuberculosis-patients identified through passive case finding(PCF) were anonymised and randomised. Two respiratory physicians and two radiologists assessed the chest x-rays.Results: The normal chest x-ray rate was higher in the non-tuberculosis control group (median = 32 (82.1{\%}), range = 74.4{\%} - 100{\%}), compared to the SSC group (median = 7 (17.9{\%}), range = 10.3{\%} - 33.3{\%}), and the PCF controls (median = 3(7.7{\%}), range = 2.6{\%} - 15.4{\%}). In the SSC group 14 (35.9{\%}) were categorized as normal by at least one study participant.Conclusion: A substantial minority of patients diagnosed with tuberculosis by spot sputum culture screening, and through passive case finding would not have been identified with chest x-ray alone, highlighting that a normal chest x-ray does not exclude pulmonary tuberculosis.",
author = "Ema Rastoder and Shaker, {Saher Burhan} and Matiullah Naqibullah and Wille, {Mathilde Marie Winkler} and Mette Lund and Wilcke, {Jon Torgny} and Niels Seersholm and Jensen, {Sidse Graff}",
note = "{\circledC} 2019 The Authors. Published by Elsevier Ltd.",
year = "2019",
doi = "10.1016/j.jctube.2019.01.003",
language = "English",
volume = "14",
pages = "26--30",
journal = "Journal of Clinical Tuberculosis and Other Mycobacterial Diseases",
issn = "2405-5794",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Chest x-ray findings in tuberculosis patients identified by passive and active case finding

T2 - A retrospective study

AU - Rastoder, Ema

AU - Shaker, Saher Burhan

AU - Naqibullah, Matiullah

AU - Wille, Mathilde Marie Winkler

AU - Lund, Mette

AU - Wilcke, Jon Torgny

AU - Seersholm, Niels

AU - Jensen, Sidse Graff

N1 - © 2019 The Authors. Published by Elsevier Ltd.

PY - 2019

Y1 - 2019

N2 - Background: Chest x-ray is central in screening and diagnosis of tuberculosis. However, sputum culture remains gold standard for diagnosis.Aim: To establish the rate of normal chest x-rays in tuberculosis patients found by spot sputum culture screening, and compare them to a group identified through passive case finding.Method: Chest x-rays from 39 culture-positive patients, identified by spot sputum culture screening in Copenhagen from 2012 to 2014, were included in the study (spot sputum culture group(SSC)). 39 normal chest x-rays from persons screened by mobile x-ray, and 39 chest x-rays from tuberculosis-patients identified through passive case finding(PCF) were anonymised and randomised. Two respiratory physicians and two radiologists assessed the chest x-rays.Results: The normal chest x-ray rate was higher in the non-tuberculosis control group (median = 32 (82.1%), range = 74.4% - 100%), compared to the SSC group (median = 7 (17.9%), range = 10.3% - 33.3%), and the PCF controls (median = 3(7.7%), range = 2.6% - 15.4%). In the SSC group 14 (35.9%) were categorized as normal by at least one study participant.Conclusion: A substantial minority of patients diagnosed with tuberculosis by spot sputum culture screening, and through passive case finding would not have been identified with chest x-ray alone, highlighting that a normal chest x-ray does not exclude pulmonary tuberculosis.

AB - Background: Chest x-ray is central in screening and diagnosis of tuberculosis. However, sputum culture remains gold standard for diagnosis.Aim: To establish the rate of normal chest x-rays in tuberculosis patients found by spot sputum culture screening, and compare them to a group identified through passive case finding.Method: Chest x-rays from 39 culture-positive patients, identified by spot sputum culture screening in Copenhagen from 2012 to 2014, were included in the study (spot sputum culture group(SSC)). 39 normal chest x-rays from persons screened by mobile x-ray, and 39 chest x-rays from tuberculosis-patients identified through passive case finding(PCF) were anonymised and randomised. Two respiratory physicians and two radiologists assessed the chest x-rays.Results: The normal chest x-ray rate was higher in the non-tuberculosis control group (median = 32 (82.1%), range = 74.4% - 100%), compared to the SSC group (median = 7 (17.9%), range = 10.3% - 33.3%), and the PCF controls (median = 3(7.7%), range = 2.6% - 15.4%). In the SSC group 14 (35.9%) were categorized as normal by at least one study participant.Conclusion: A substantial minority of patients diagnosed with tuberculosis by spot sputum culture screening, and through passive case finding would not have been identified with chest x-ray alone, highlighting that a normal chest x-ray does not exclude pulmonary tuberculosis.

U2 - 10.1016/j.jctube.2019.01.003

DO - 10.1016/j.jctube.2019.01.003

M3 - Journal article

VL - 14

SP - 26

EP - 30

JO - Journal of Clinical Tuberculosis and Other Mycobacterial Diseases

JF - Journal of Clinical Tuberculosis and Other Mycobacterial Diseases

SN - 2405-5794

ER -

ID: 58383321