Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis

Torben L Sørensen; Hanne Roed; Finn Sellebjerg

doi:10.1016/s0165-5728(01)00453-2

Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis

Torben L Sørensen, Hanne Roed, Finn Sellebjerg

34 Citations (Scopus)

Abstract

We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-beta-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment.

Original language	English
Journal	Journal of Neuroimmunology
Volume	122
Issue number	1-2
Pages (from-to)	125-31
Number of pages	7
ISSN	0165-5728
DOIs	https://doi.org/10.1016/s0165-5728(01)00453-2
Publication status	Published - Jan 2002
Externally published	Yes

Keywords

Adjuvants, Immunologic/administration & dosage
Adult
B-Lymphocytes/metabolism
Cerebrospinal Fluid/cytology
Demyelinating Diseases/drug therapy
Female
Flow Cytometry
Humans
Interferon-beta/administration & dosage
Male
Middle Aged
Multiple Sclerosis, Chronic Progressive/drug therapy
Multiple Sclerosis, Relapsing-Remitting/drug therapy
Receptors, CCR5/biosynthesis
Receptors, CXCR3
Receptors, CXCR5
Receptors, Chemokine/biosynthesis
Receptors, Cytokine/biosynthesis

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10.1016/s0165-5728(01)00453-2

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title = "Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis",

abstract = "We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-beta-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment.",

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author = "S{\o}rensen, \{Torben L\} and Hanne Roed and Finn Sellebjerg",

year = "2002",

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doi = "10.1016/s0165-5728(01)00453-2",

language = "English",

volume = "122",

pages = "125--31",

journal = "Journal of Neuroimmunology",

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TY - JOUR

T1 - Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis

AU - Sørensen, Torben L

AU - Roed, Hanne

AU - Sellebjerg, Finn

PY - 2002/1

Y1 - 2002/1

N2 - We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-beta-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment.

AB - We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-beta-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment.

KW - Adjuvants, Immunologic/administration & dosage

KW - Adult

KW - B-Lymphocytes/metabolism

KW - Cerebrospinal Fluid/cytology

KW - Demyelinating Diseases/drug therapy

KW - Female

KW - Flow Cytometry

KW - Humans

KW - Interferon-beta/administration & dosage

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis, Chronic Progressive/drug therapy

KW - Multiple Sclerosis, Relapsing-Remitting/drug therapy

KW - Receptors, CCR5/biosynthesis

KW - Receptors, CXCR3

KW - Receptors, CXCR5

KW - Receptors, Chemokine/biosynthesis

KW - Receptors, Cytokine/biosynthesis

UR - https://www.scopus.com/pages/publications/0036147311

U2 - 10.1016/s0165-5728(01)00453-2

DO - 10.1016/s0165-5728(01)00453-2

M3 - Journal article

C2 - 11777551

SN - 0165-5728

VL - 122

SP - 125

EP - 131

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis

Abstract

Keywords

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