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Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes

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  • Marita Westhrin
  • Siv Helen Moen
  • Ida Bruun Kristensen
  • Glenn Buene
  • Anne Kærsgaard Mylin
  • Ingemar Turesson
  • Niels Abildgaard
  • Anders Waage
  • Therese Standal
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Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it increases with disease progression. We found that chemerin is expressed by stromal cells and preadipocytes, whereas its receptor CCRL2 is expressed by primary myeloma cells, suggesting a paracrine signaling loop between bone marrow stromal cells/adipocytes and myeloma cells. This is the first study exploring chemerin and its receptors in multiple myeloma.

Original languageEnglish
JournalBiomarker Research
Volume6
Issue number21
Pages (from-to)4
ISSN2050-7771
DOIs
Publication statusPublished - 2018

ID: 56670289