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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Characterization of the Oral and Gut Microbiota in Patients with Psoriatic Diseases: A Systematic Review

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Advances in technology have led to an increased number of studies investigating the microbiome in patients with psoriasis. This systematic review examined data regarding the oral and gut microbiota in patients with psoriasis and/or psoriatic arthritis and the effect of probiotics on the microbiota and severity of psoriasis. Of 1,643 studies, 23 were included (22 observational, 1 interventional). Studies examined the microbiota using culture or 16S rRNA gene sequencing analysis. All culture-based studies identified an increased presence of oral Candida in patients with psoriasis, whereas small variations in the oral microbiota were found in a 16S rRNA gene-based study. All 16S rRNA gene sequencing based studies agreed that the gut microbiota of patients with psoriatic disease differed from that of healthy controls, but the results were heterogeneous. Probiotics were associated with a significant improvement in the severity of psoriasis, but did not change microbiota. Overall, studies lacked relevant inclusion criteria and baseline information. In conclusion, the role of the microbiota in patients with psoriasis requires further investigation using more robust methods.

Original languageEnglish
JournalActa Dermato-Venereologica
Volume101
Issue number7
Pages (from-to)adv00512
ISSN0001-5555
DOIs
Publication statusPublished - 30 Jul 2021

    Research areas

  • Arthritis, Psoriatic/diagnosis, Gastrointestinal Microbiome, Humans, Microbiota, Psoriasis/diagnosis, RNA, Ribosomal, 16S/genetics, microbiota, psoriasis, immune system, psoriatic arthritis, probiotics

ID: 67624958