Characterization of the in Vitro Effects of Glucocorticosteroids on NK Cell Activity

B. K. Pedersen; J. M. Beyer

doi:10.1111/j.1398-9995.1986.tb00303.x

Characterization of the in Vitro Effects of Glucocorticosteroids on NK Cell Activity

B. K. Pedersen^*, J. M. Beyer

^*Corresponding author for this work

33 Citations (Scopus)

Abstract

The NK cell activity of mononuclear cells as well as monocyte‐depleted, Percoll‐fractionated, NK cell‐enriched effector cells against K 562 target cells was inhibited by methylprednisolone (MP) and hydrocortisone (HC) in a dose‐dependent manner. The effector/target cell conjugate formation was studied in a single cell agarose assay, and it was shown that MP and HC partly inhibited the NK cell activity by inhibition of the adhesion of effector cells to target.

Original language	English
Journal	Allergy
Volume	41
Issue number	3
Pages (from-to)	220-224
Number of pages	5
ISSN	0105-4538
DOIs	https://doi.org/10.1111/j.1398-9995.1986.tb00303.x
Publication status	Published - Apr 1986
Externally published	Yes

Keywords

hydrocortisone
methylprednisolone
natural killer cell activity

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10.1111/j.1398-9995.1986.tb00303.x

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abstract = "The NK cell activity of mononuclear cells as well as monocyte‐depleted, Percoll‐fractionated, NK cell‐enriched effector cells against K 562 target cells was inhibited by methylprednisolone (MP) and hydrocortisone (HC) in a dose‐dependent manner. The effector/target cell conjugate formation was studied in a single cell agarose assay, and it was shown that MP and HC partly inhibited the NK cell activity by inhibition of the adhesion of effector cells to target.",

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AU - Pedersen, B. K.

AU - Beyer, J. M.

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N2 - The NK cell activity of mononuclear cells as well as monocyte‐depleted, Percoll‐fractionated, NK cell‐enriched effector cells against K 562 target cells was inhibited by methylprednisolone (MP) and hydrocortisone (HC) in a dose‐dependent manner. The effector/target cell conjugate formation was studied in a single cell agarose assay, and it was shown that MP and HC partly inhibited the NK cell activity by inhibition of the adhesion of effector cells to target.

AB - The NK cell activity of mononuclear cells as well as monocyte‐depleted, Percoll‐fractionated, NK cell‐enriched effector cells against K 562 target cells was inhibited by methylprednisolone (MP) and hydrocortisone (HC) in a dose‐dependent manner. The effector/target cell conjugate formation was studied in a single cell agarose assay, and it was shown that MP and HC partly inhibited the NK cell activity by inhibition of the adhesion of effector cells to target.

KW - hydrocortisone

KW - methylprednisolone

KW - natural killer cell activity

UR - https://www.scopus.com/pages/publications/0022466229

U2 - 10.1111/j.1398-9995.1986.tb00303.x

DO - 10.1111/j.1398-9995.1986.tb00303.x

M3 - Journal article

C2 - 2424334

AN - SCOPUS:0022466229

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SP - 220

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JO - Allergy

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IS - 3

ER -

Characterization of the in Vitro Effects of Glucocorticosteroids on NK Cell Activity

Abstract

Keywords

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