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Characterization of the contractile P2Y14 receptor in mouse coronary and cerebral arteries

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Extracellular UDP-glucose can activate the purinergic P2Y14 receptor. The aim of the present study was to examine the physiological importance of P2Y14 receptors in the vasculature. The data presented herein show that UDP-glucose causes contraction in mouse coronary and basilar arteries. The EC50 values and immunohistochemistry illustrated the strongest P2Y14 receptor expression in the basilar artery. In the presence of pertussis toxin, UDP-glucose inhibited contraction in coronary arteries and in the basilar artery it surprisingly caused relaxation. After organ culture of the coronary artery, the EC50 value decreased and an increased staining for the P2Y14 receptor was observed, showing receptor plasticity.

Original languageEnglish
JournalF E B S Letters
Volume588
Issue number17
Pages (from-to)2936-43
Number of pages8
ISSN0014-5793
DOIs
Publication statusPublished - 25 Aug 2014

    Research areas

  • Animals, Cerebral Arteries, Coronary Vessels, Female, In Vitro Techniques, Male, Mice, Mice, Inbred BALB C, Muscle Contraction, Pertussis Toxin, Receptors, Purinergic P2Y, Up-Regulation, Uridine Diphosphate Glucose

ID: 44845660