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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Characterization of naïve, memory and effector T cells in progressive multiple sclerosis

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  1. B cells from patients with multiple sclerosis have a pathogenic phenotype and increased LTα and TGFβ1 response

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  2. Inflammatory markers of CHMP2B-mediated frontotemporal dementia

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  3. Immunological effects of methylprednisolone pulse treatment in progressive multiple sclerosis

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  1. Diagnostic value of oligoclonal bands in children: A Nationwide Population-Based Cohort Study

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  2. Smoking is associated with increased disease activity during natalizumab treatment in multiple sclerosis

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  3. Functional neuroimaging of recovery from motor conversion disorder: A case report

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  4. Structural and cognitive correlates of fatigue in progressive multiple sclerosis

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We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all subtypes of MS, and CD26+ CD28+ CD8+ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d+ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.

Original languageEnglish
JournalJournal of Neuroimmunology
Volume310
Pages (from-to)17-25
Number of pages9
ISSN0165-5728
DOIs
Publication statusPublished - 15 Sep 2017

    Research areas

  • Adult, Antigens, CD, Cross-Sectional Studies, Disability Evaluation, Female, Flow Cytometry, Humans, Immunologic Factors, Immunologic Memory, Lymphocyte Activation, Male, Middle Aged, Multiple Sclerosis, Natalizumab, Statistics, Nonparametric, T-Lymphocyte Subsets, Journal Article

ID: 52217545