Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey

Loris Pironi; Ezra Steiger; Francisca Joly; Palle B Jeppesen; Geert Wanten; Anna S Sasdelli; Cecile Chambrier; Umberto Aimasso; Manpreet S Mundi; Kinga Szczepanek; Amelia Jukes; Miriam Theilla; Marek Kunecki; Joanne Daniels; Mireille Serlie; Florian Poullenot; Sheldon C Cooper; Henrik H Rasmussen; Charlene Compher; David Seguy; Adriana Crivelli; Lidia Santarpia; Francesco W Guglielmi; Nada Rotovnik Kozjek; Stéphane M Schneider; Lars Ellegard; Ronan Thibault; Przemysław Matras; Konrad Matysiak; Andrè Van Gossum; Alastair Forbes; Nicola Wyer; Marina Taus; Nuria M Virgili; Margie O'Callaghan; Brooke Chapman; Emma Osland; Cristina Cuerda; Gábor Udvarhelyi; Lynn Jones; Andre D Won Lee; Luisa Masconale; Paolo Orlandoni; Corrado Spaggiari; Marta Bueno Díez; Maryana Doitchinova-Simeonova; Aurora E Serralde-Zúñiga; Gabriel Olveira; Zeljko Krznaric; Laszlo Czako; Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN

doi:10.1016/j.clnesp.2021.07.004

Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey

Loris Pironi, Ezra Steiger, Francisca Joly, Palle B Jeppesen, Geert Wanten, Anna S Sasdelli, Cecile Chambrier, Umberto Aimasso, Manpreet S Mundi, Kinga Szczepanek, Amelia Jukes, Miriam Theilla, Marek Kunecki, Joanne Daniels, Mireille Serlie, Florian Poullenot, Sheldon C Cooper, Henrik H Rasmussen, Charlene Compher, David SeguyAdriana Crivelli, Lidia Santarpia, Francesco W Guglielmi, Nada Rotovnik Kozjek, Stéphane M Schneider, Lars Ellegard, Ronan Thibault, Przemysław Matras, Konrad Matysiak, Andrè Van Gossum, Alastair Forbes, Nicola Wyer, Marina Taus, Nuria M Virgili, Margie O'Callaghan, Brooke Chapman, Emma Osland, Cristina Cuerda, Gábor Udvarhelyi, Lynn Jones, Andre D Won Lee, Luisa Masconale, Paolo Orlandoni, Corrado Spaggiari, Marta Bueno Díez, Maryana Doitchinova-Simeonova, Aurora E Serralde-Zúñiga, Gabriel Olveira, Zeljko Krznaric, Laszlo Czako, Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN

48 Citations (Scopus)

Abstract

BACKGROUND AND AIMS: The case-mix of patients with intestinal failure due to short bowel syndrome (SBS-IF) can differ among centres and may also be affected by the timeframe of data collection. Therefore, the ESPEN international multicenter cross-sectional survey was analyzed to compare the characteristics of SBS-IF cohorts collected within the same timeframe in different countries.

METHODS: The study included 1880 adult SBS-IF patients collected in 2015 by 65 centres from 22 countries. The demographic, nutritional, SBS type (end jejunostomy, SBS-J; jejuno-colic anastomosis, SBS-JC; jejunoileal anastomosis with an intact colon and ileocecal valve, SBS-JIC), underlying disease and intravenous supplementation (IVS) characteristics were analyzed. IVS was classified as fluid and electrolyte alone (FE) or parenteral nutrition admixture (PN). The mean daily IVS volume, calculated on a weekly basis, was categorized as <1, 1-2, 2-3 and >3 L/day.

RESULTS: In the entire group: 60.7% were females and SBS-J comprised 60% of cases, while mesenteric ischaemia (MI) and Crohn' disease (CD) were the main underlying diseases. IVS dependency was longer than 3 years in around 50% of cases; IVS was infused ≥5 days/week in 75% and FE in 10% of cases. Within the SBS-IF cohort: CD was twice and thrice more frequent in SBS-J than SBS-JC and SBS-JIC, respectively, while MI was more frequent in SBS-JC and SBS-JIC. Within countries: SBS-J represented 75% or more of patients in UK and Denmark and 50-60% in the other countries, except Poland where SBS-JC prevailed. CD was the main underlying disease in UK, USA, Denmark and The Netherlands, while MI prevailed in France, Italy and Poland.

CONCLUSIONS: SBS-IF type is primarily determined by the underlying disease, with significant variation between countries. These novel data will be useful for planning and managing both clinical activity and research studies on SBS.

Original language	English
Journal	Clinical Nutrition ESPEN
Volume	45
Pages (from-to)	433-441
Number of pages	9
ISSN	2405-4577
DOIs	https://doi.org/10.1016/j.clnesp.2021.07.004
Publication status	Published - Oct 2021

Keywords

Epidemiology
Home parenteral nutrition
Intestinal failure
Intravenous supplementation
Short bowel syndrome

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10.1016/j.clnesp.2021.07.004

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Pironi, L., Steiger, E., Joly, F., Jeppesen, P. B., Wanten, G., Sasdelli, A. S., Chambrier, C., Aimasso, U., Mundi, M. S., Szczepanek, K., Jukes, A., Theilla, M., Kunecki, M., Daniels, J., Serlie, M., Poullenot, F., Cooper, S. C., Rasmussen, H. H., Compher, C., ... Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN (2021). Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey. Clinical Nutrition ESPEN , 45, 433-441. https://doi.org/10.1016/j.clnesp.2021.07.004

Pironi, L, Steiger, E, Joly, F, Jeppesen, PB, Wanten, G, Sasdelli, AS, Chambrier, C, Aimasso, U, Mundi, MS, Szczepanek, K, Jukes, A, Theilla, M, Kunecki, M, Daniels, J, Serlie, M, Poullenot, F, Cooper, SC, Rasmussen, HH, Compher, C, Seguy, D, Crivelli, A, Santarpia, L, Guglielmi, FW, Kozjek, NR, Schneider, SM, Ellegard, L, Thibault, R, Matras, P, Matysiak, K, Van Gossum, A, Forbes, A, Wyer, N, Taus, M, Virgili, NM, O'Callaghan, M, Chapman, B, Osland, E, Cuerda, C, Udvarhelyi, G, Jones, L, Won Lee, AD, Masconale, L, Orlandoni, P, Spaggiari, C, Díez, MB, Doitchinova-Simeonova, M, Serralde-Zúñiga, AE, Olveira, G, Krznaric, Z, Czako, L & Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN 2021, 'Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey', Clinical Nutrition ESPEN , vol. 45, pp. 433-441. https://doi.org/10.1016/j.clnesp.2021.07.004

@article{74b55c769d2e45cc80ab2babcbb808e6,

title = "Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey",

abstract = "BACKGROUND AND AIMS: The case-mix of patients with intestinal failure due to short bowel syndrome (SBS-IF) can differ among centres and may also be affected by the timeframe of data collection. Therefore, the ESPEN international multicenter cross-sectional survey was analyzed to compare the characteristics of SBS-IF cohorts collected within the same timeframe in different countries.METHODS: The study included 1880 adult SBS-IF patients collected in 2015 by 65 centres from 22 countries. The demographic, nutritional, SBS type (end jejunostomy, SBS-J; jejuno-colic anastomosis, SBS-JC; jejunoileal anastomosis with an intact colon and ileocecal valve, SBS-JIC), underlying disease and intravenous supplementation (IVS) characteristics were analyzed. IVS was classified as fluid and electrolyte alone (FE) or parenteral nutrition admixture (PN). The mean daily IVS volume, calculated on a weekly basis, was categorized as <1, 1-2, 2-3 and >3 L/day.RESULTS: In the entire group: 60.7\% were females and SBS-J comprised 60\% of cases, while mesenteric ischaemia (MI) and Crohn' disease (CD) were the main underlying diseases. IVS dependency was longer than 3 years in around 50\% of cases; IVS was infused ≥5 days/week in 75\% and FE in 10\% of cases. Within the SBS-IF cohort: CD was twice and thrice more frequent in SBS-J than SBS-JC and SBS-JIC, respectively, while MI was more frequent in SBS-JC and SBS-JIC. Within countries: SBS-J represented 75\% or more of patients in UK and Denmark and 50-60\% in the other countries, except Poland where SBS-JC prevailed. CD was the main underlying disease in UK, USA, Denmark and The Netherlands, while MI prevailed in France, Italy and Poland.CONCLUSIONS: SBS-IF type is primarily determined by the underlying disease, with significant variation between countries. These novel data will be useful for planning and managing both clinical activity and research studies on SBS.",

keywords = "Epidemiology, Home parenteral nutrition, Intestinal failure, Intravenous supplementation, Short bowel syndrome",

author = "Loris Pironi and Ezra Steiger and Francisca Joly and Jeppesen, \{Palle B\} and Geert Wanten and Sasdelli, \{Anna S\} and Cecile Chambrier and Umberto Aimasso and Mundi, \{Manpreet S\} and Kinga Szczepanek and Amelia Jukes and Miriam Theilla and Marek Kunecki and Joanne Daniels and Mireille Serlie and Florian Poullenot and Cooper, \{Sheldon C\} and Rasmussen, \{Henrik H\} and Charlene Compher and David Seguy and Adriana Crivelli and Lidia Santarpia and Guglielmi, \{Francesco W\} and Kozjek, \{Nada Rotovnik\} and Schneider, \{St{\'e}phane M\} and Lars Ellegard and Ronan Thibault and Przemys{\l}aw Matras and Konrad Matysiak and \{Van Gossum\}, Andr{\`e} and Alastair Forbes and Nicola Wyer and Marina Taus and Virgili, \{Nuria M\} and Margie O'Callaghan and Brooke Chapman and Emma Osland and Cristina Cuerda and G{\'a}bor Udvarhelyi and Lynn Jones and \{Won Lee\}, \{Andre D\} and Luisa Masconale and Paolo Orlandoni and Corrado Spaggiari and D{\'i}ez, \{Marta Bueno\} and Maryana Doitchinova-Simeonova and Serralde-Z{\'u}{\~n}iga, \{Aurora E\} and Gabriel Olveira and Zeljko Krznaric and Laszlo Czako and \{Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN\}",

year = "2021",

month = oct,

doi = "10.1016/j.clnesp.2021.07.004",

language = "English",

volume = "45",

pages = "433--441",

journal = "Clinical Nutrition ESPEN ",

issn = "2405-4577",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome

T2 - An international multicenter survey

AU - Pironi, Loris

AU - Steiger, Ezra

AU - Joly, Francisca

AU - Jeppesen, Palle B

AU - Wanten, Geert

AU - Sasdelli, Anna S

AU - Chambrier, Cecile

AU - Aimasso, Umberto

AU - Mundi, Manpreet S

AU - Szczepanek, Kinga

AU - Jukes, Amelia

AU - Theilla, Miriam

AU - Kunecki, Marek

AU - Daniels, Joanne

AU - Serlie, Mireille

AU - Poullenot, Florian

AU - Cooper, Sheldon C

AU - Rasmussen, Henrik H

AU - Compher, Charlene

AU - Seguy, David

AU - Crivelli, Adriana

AU - Santarpia, Lidia

AU - Guglielmi, Francesco W

AU - Kozjek, Nada Rotovnik

AU - Schneider, Stéphane M

AU - Ellegard, Lars

AU - Thibault, Ronan

AU - Matras, Przemysław

AU - Matysiak, Konrad

AU - Van Gossum, Andrè

AU - Forbes, Alastair

AU - Wyer, Nicola

AU - Taus, Marina

AU - Virgili, Nuria M

AU - O'Callaghan, Margie

AU - Chapman, Brooke

AU - Osland, Emma

AU - Cuerda, Cristina

AU - Udvarhelyi, Gábor

AU - Jones, Lynn

AU - Won Lee, Andre D

AU - Masconale, Luisa

AU - Orlandoni, Paolo

AU - Spaggiari, Corrado

AU - Díez, Marta Bueno

AU - Doitchinova-Simeonova, Maryana

AU - Serralde-Zúñiga, Aurora E

AU - Olveira, Gabriel

AU - Krznaric, Zeljko

AU - Czako, Laszlo

AU - Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN

PY - 2021/10

Y1 - 2021/10

N2 - BACKGROUND AND AIMS: The case-mix of patients with intestinal failure due to short bowel syndrome (SBS-IF) can differ among centres and may also be affected by the timeframe of data collection. Therefore, the ESPEN international multicenter cross-sectional survey was analyzed to compare the characteristics of SBS-IF cohorts collected within the same timeframe in different countries.METHODS: The study included 1880 adult SBS-IF patients collected in 2015 by 65 centres from 22 countries. The demographic, nutritional, SBS type (end jejunostomy, SBS-J; jejuno-colic anastomosis, SBS-JC; jejunoileal anastomosis with an intact colon and ileocecal valve, SBS-JIC), underlying disease and intravenous supplementation (IVS) characteristics were analyzed. IVS was classified as fluid and electrolyte alone (FE) or parenteral nutrition admixture (PN). The mean daily IVS volume, calculated on a weekly basis, was categorized as <1, 1-2, 2-3 and >3 L/day.RESULTS: In the entire group: 60.7% were females and SBS-J comprised 60% of cases, while mesenteric ischaemia (MI) and Crohn' disease (CD) were the main underlying diseases. IVS dependency was longer than 3 years in around 50% of cases; IVS was infused ≥5 days/week in 75% and FE in 10% of cases. Within the SBS-IF cohort: CD was twice and thrice more frequent in SBS-J than SBS-JC and SBS-JIC, respectively, while MI was more frequent in SBS-JC and SBS-JIC. Within countries: SBS-J represented 75% or more of patients in UK and Denmark and 50-60% in the other countries, except Poland where SBS-JC prevailed. CD was the main underlying disease in UK, USA, Denmark and The Netherlands, while MI prevailed in France, Italy and Poland.CONCLUSIONS: SBS-IF type is primarily determined by the underlying disease, with significant variation between countries. These novel data will be useful for planning and managing both clinical activity and research studies on SBS.

AB - BACKGROUND AND AIMS: The case-mix of patients with intestinal failure due to short bowel syndrome (SBS-IF) can differ among centres and may also be affected by the timeframe of data collection. Therefore, the ESPEN international multicenter cross-sectional survey was analyzed to compare the characteristics of SBS-IF cohorts collected within the same timeframe in different countries.METHODS: The study included 1880 adult SBS-IF patients collected in 2015 by 65 centres from 22 countries. The demographic, nutritional, SBS type (end jejunostomy, SBS-J; jejuno-colic anastomosis, SBS-JC; jejunoileal anastomosis with an intact colon and ileocecal valve, SBS-JIC), underlying disease and intravenous supplementation (IVS) characteristics were analyzed. IVS was classified as fluid and electrolyte alone (FE) or parenteral nutrition admixture (PN). The mean daily IVS volume, calculated on a weekly basis, was categorized as <1, 1-2, 2-3 and >3 L/day.RESULTS: In the entire group: 60.7% were females and SBS-J comprised 60% of cases, while mesenteric ischaemia (MI) and Crohn' disease (CD) were the main underlying diseases. IVS dependency was longer than 3 years in around 50% of cases; IVS was infused ≥5 days/week in 75% and FE in 10% of cases. Within the SBS-IF cohort: CD was twice and thrice more frequent in SBS-J than SBS-JC and SBS-JIC, respectively, while MI was more frequent in SBS-JC and SBS-JIC. Within countries: SBS-J represented 75% or more of patients in UK and Denmark and 50-60% in the other countries, except Poland where SBS-JC prevailed. CD was the main underlying disease in UK, USA, Denmark and The Netherlands, while MI prevailed in France, Italy and Poland.CONCLUSIONS: SBS-IF type is primarily determined by the underlying disease, with significant variation between countries. These novel data will be useful for planning and managing both clinical activity and research studies on SBS.

KW - Epidemiology

KW - Home parenteral nutrition

KW - Intestinal failure

KW - Intravenous supplementation

KW - Short bowel syndrome

UR - https://www.scopus.com/pages/publications/85113146967

U2 - 10.1016/j.clnesp.2021.07.004

DO - 10.1016/j.clnesp.2021.07.004

M3 - Journal article

C2 - 34620351

SN - 2405-4577

VL - 45

SP - 433

EP - 441

JO - Clinical Nutrition ESPEN

JF - Clinical Nutrition ESPEN

ER -

Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey

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