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Characteristics and early outcomes of patients hospitalised for COVID-19 in North Zealand, Denmark

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@article{a2cf754fdaf44f8681f79b1d3b03bee9,
title = "Characteristics and early outcomes of patients hospitalised for COVID-19 in North Zealand, Denmark",
abstract = "INTRODUCTION: Coronavirus disease 2019 (COVID-19) is an ongoing pandemic associated with significant morbidity and mortality worldwide. Limited data are available describing the clinical presentation and outcomes of hospitalised COVID-19 patients in Europe.METHODS: This was a single-centre retrospective chart review of all patients with COVID-19 admitted to the North Zealand Hospital in Denmark between 1 March and 4 May 2020. Main outcomes include major therapeutic interventions during hospitalisation, such as invasive mechanical ventilation, as well as death.RESULTS: A total of 115 patients were included, including four infants. The median age of adults was 68 years and 40{\%} were female. At admission, 55 (50{\%}) patients had a fever, 29 (26{\%}) had a respiratory rate exceeding 24 breaths/minute, and 78 (70{\%}) received supplemental oxygen. The prevalence of co-infection was 13{\%}. Twenty patients (18{\%}) (median age: 64 years; 15{\%} female) were treated in the intensive care unit. Twelve (10.4{\%}) received invasive mechanical ventilation and three (2.6{\%}) renal replacement therapy. Nine patients (8{\%}) developed pulmonary embolism. Sixteen patients (14{\%}) died. Among patients requiring mechanical ventilation (n = 12), seven (6.1{\%}) were discharged alive, four (3.4{\%}) died and one (0.9{\%}) was still hospitalised.CONCLUSION: In this cohort of hospitalised COVID-19 patients, mortality was lower than in other Danish and European case series.FUNDING: none.TRIAL REGISTRATION: not relevant.",
keywords = "Adult, Aged, Betacoronavirus, Coronavirus Infections/epidemiology, Denmark/epidemiology, Female, Hospitalization/trends, Humans, Intensive Care Units/statistics & numerical data, Male, Middle Aged, Pandemics, Pneumonia, Viral/epidemiology, Prevalence, Retrospective Studies",
author = "Lendorf, {Maria Elisabeth} and Boisen, {Mogens Karsb{\o}l} and Kristensen, {Peter Lommer} and L{\o}kkegaard, {Ellen Christine Leth} and Krog, {Sebastian Moretto} and Lisbet Brandi and Brinth, {Louise Schouborg} and Nols{\"o}e, {R{\'u}na Louise Mortansd{\'o}ttir} and Camilla Ryrs{\o} and Pia Eiken and Bestle, {Morten Heiberg} and J{\o}rgensen, {Inger Merete} and Ulrik Pedersen-Bjergaard and Birgitte Lindegaard and Christensen, {Thomas Broe} and Fischer, {Thea K{\o}lsen}",
note = "Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.",
year = "2020",
language = "English",
volume = "67",
journal = "Danish Medical Bulletin (Online)",
issn = "1603-9629",
publisher = "Almindelige Danske Laegeforening",
number = "9",

}

RIS

TY - JOUR

T1 - Characteristics and early outcomes of patients hospitalised for COVID-19 in North Zealand, Denmark

AU - Lendorf, Maria Elisabeth

AU - Boisen, Mogens Karsbøl

AU - Kristensen, Peter Lommer

AU - Løkkegaard, Ellen Christine Leth

AU - Krog, Sebastian Moretto

AU - Brandi, Lisbet

AU - Brinth, Louise Schouborg

AU - Nolsöe, Rúna Louise Mortansdóttir

AU - Ryrsø, Camilla

AU - Eiken, Pia

AU - Bestle, Morten Heiberg

AU - Jørgensen, Inger Merete

AU - Pedersen-Bjergaard, Ulrik

AU - Lindegaard, Birgitte

AU - Christensen, Thomas Broe

AU - Fischer, Thea Kølsen

N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

PY - 2020

Y1 - 2020

N2 - INTRODUCTION: Coronavirus disease 2019 (COVID-19) is an ongoing pandemic associated with significant morbidity and mortality worldwide. Limited data are available describing the clinical presentation and outcomes of hospitalised COVID-19 patients in Europe.METHODS: This was a single-centre retrospective chart review of all patients with COVID-19 admitted to the North Zealand Hospital in Denmark between 1 March and 4 May 2020. Main outcomes include major therapeutic interventions during hospitalisation, such as invasive mechanical ventilation, as well as death.RESULTS: A total of 115 patients were included, including four infants. The median age of adults was 68 years and 40% were female. At admission, 55 (50%) patients had a fever, 29 (26%) had a respiratory rate exceeding 24 breaths/minute, and 78 (70%) received supplemental oxygen. The prevalence of co-infection was 13%. Twenty patients (18%) (median age: 64 years; 15% female) were treated in the intensive care unit. Twelve (10.4%) received invasive mechanical ventilation and three (2.6%) renal replacement therapy. Nine patients (8%) developed pulmonary embolism. Sixteen patients (14%) died. Among patients requiring mechanical ventilation (n = 12), seven (6.1%) were discharged alive, four (3.4%) died and one (0.9%) was still hospitalised.CONCLUSION: In this cohort of hospitalised COVID-19 patients, mortality was lower than in other Danish and European case series.FUNDING: none.TRIAL REGISTRATION: not relevant.

AB - INTRODUCTION: Coronavirus disease 2019 (COVID-19) is an ongoing pandemic associated with significant morbidity and mortality worldwide. Limited data are available describing the clinical presentation and outcomes of hospitalised COVID-19 patients in Europe.METHODS: This was a single-centre retrospective chart review of all patients with COVID-19 admitted to the North Zealand Hospital in Denmark between 1 March and 4 May 2020. Main outcomes include major therapeutic interventions during hospitalisation, such as invasive mechanical ventilation, as well as death.RESULTS: A total of 115 patients were included, including four infants. The median age of adults was 68 years and 40% were female. At admission, 55 (50%) patients had a fever, 29 (26%) had a respiratory rate exceeding 24 breaths/minute, and 78 (70%) received supplemental oxygen. The prevalence of co-infection was 13%. Twenty patients (18%) (median age: 64 years; 15% female) were treated in the intensive care unit. Twelve (10.4%) received invasive mechanical ventilation and three (2.6%) renal replacement therapy. Nine patients (8%) developed pulmonary embolism. Sixteen patients (14%) died. Among patients requiring mechanical ventilation (n = 12), seven (6.1%) were discharged alive, four (3.4%) died and one (0.9%) was still hospitalised.CONCLUSION: In this cohort of hospitalised COVID-19 patients, mortality was lower than in other Danish and European case series.FUNDING: none.TRIAL REGISTRATION: not relevant.

KW - Adult

KW - Aged

KW - Betacoronavirus

KW - Coronavirus Infections/epidemiology

KW - Denmark/epidemiology

KW - Female

KW - Hospitalization/trends

KW - Humans

KW - Intensive Care Units/statistics & numerical data

KW - Male

KW - Middle Aged

KW - Pandemics

KW - Pneumonia, Viral/epidemiology

KW - Prevalence

KW - Retrospective Studies

M3 - Journal article

VL - 67

JO - Danish Medical Bulletin (Online)

JF - Danish Medical Bulletin (Online)

SN - 1603-9629

IS - 9

M1 - A06200428

ER -

ID: 60767331