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Characteristic Features of Infrared Thermographic Imaging in Primary Raynaud's Phenomenon

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@article{c74d34c1f0414af5bbf0d6b6c599eca6,
title = "Characteristic Features of Infrared Thermographic Imaging in Primary Raynaud's Phenomenon",
abstract = "Raynaud's phenomenon (RP) is characterized by the episodic whitening of the fingers upon exposure to cold. Verification of the condition is crucial in vibration-exposed patients. The current verification method is outdated, but thermographic imaging seems promising as a diagnostic replacement. By investigating patients diagnosed with RP, the study aimed at developing a simple thermographic procedure that could be applied to future patients where verification of the diagnosis is needed. Twenty-two patients with primary RP and 58 healthy controls were examined using thermographic imaging after local cooling of the hands for 1 min in water of 10°C. A logistic regression model was fitted with the temperature curve characteristics to convey a predicted probability of having RP. The characteristics time to end temperature and baseline temperature were the most appropriate predictors of RP among those examined (p = 0.004 and p = 0.04, respectively). The area under the curve was 0.91. The cut-off level 0.46 yielded a sensitivity and specificity of 82% and 86%, respectively. The positive and negative predictive values were 69% and 93%, respectively. This newly developed thermographic method was able to distinguish between patients with RP and healthy controls and was easy to operate. Thus, the method showed great promise as a method for verification of RP in future patients. Trial registration: ClinicalTrials.gov NCT03094910.",
keywords = "Diagnostic method, Infrared thermographic imaging, Primary Raynaud{\textquoteright}s phenomenon, Vibration white finger",
author = "Lotte Lindberg and Bent Kristensen and Thomsen, {Jane F} and Ebbe Eldrup and Jensen, {Lars T}",
year = "2021",
month = mar,
day = "20",
doi = "10.3390/diagnostics11030558",
language = "English",
volume = "11",
journal = "Diagnostics",
issn = "2075-4418",
publisher = "M D P I AG",
number = "3",

}

RIS

TY - JOUR

T1 - Characteristic Features of Infrared Thermographic Imaging in Primary Raynaud's Phenomenon

AU - Lindberg, Lotte

AU - Kristensen, Bent

AU - Thomsen, Jane F

AU - Eldrup, Ebbe

AU - Jensen, Lars T

PY - 2021/3/20

Y1 - 2021/3/20

N2 - Raynaud's phenomenon (RP) is characterized by the episodic whitening of the fingers upon exposure to cold. Verification of the condition is crucial in vibration-exposed patients. The current verification method is outdated, but thermographic imaging seems promising as a diagnostic replacement. By investigating patients diagnosed with RP, the study aimed at developing a simple thermographic procedure that could be applied to future patients where verification of the diagnosis is needed. Twenty-two patients with primary RP and 58 healthy controls were examined using thermographic imaging after local cooling of the hands for 1 min in water of 10°C. A logistic regression model was fitted with the temperature curve characteristics to convey a predicted probability of having RP. The characteristics time to end temperature and baseline temperature were the most appropriate predictors of RP among those examined (p = 0.004 and p = 0.04, respectively). The area under the curve was 0.91. The cut-off level 0.46 yielded a sensitivity and specificity of 82% and 86%, respectively. The positive and negative predictive values were 69% and 93%, respectively. This newly developed thermographic method was able to distinguish between patients with RP and healthy controls and was easy to operate. Thus, the method showed great promise as a method for verification of RP in future patients. Trial registration: ClinicalTrials.gov NCT03094910.

AB - Raynaud's phenomenon (RP) is characterized by the episodic whitening of the fingers upon exposure to cold. Verification of the condition is crucial in vibration-exposed patients. The current verification method is outdated, but thermographic imaging seems promising as a diagnostic replacement. By investigating patients diagnosed with RP, the study aimed at developing a simple thermographic procedure that could be applied to future patients where verification of the diagnosis is needed. Twenty-two patients with primary RP and 58 healthy controls were examined using thermographic imaging after local cooling of the hands for 1 min in water of 10°C. A logistic regression model was fitted with the temperature curve characteristics to convey a predicted probability of having RP. The characteristics time to end temperature and baseline temperature were the most appropriate predictors of RP among those examined (p = 0.004 and p = 0.04, respectively). The area under the curve was 0.91. The cut-off level 0.46 yielded a sensitivity and specificity of 82% and 86%, respectively. The positive and negative predictive values were 69% and 93%, respectively. This newly developed thermographic method was able to distinguish between patients with RP and healthy controls and was easy to operate. Thus, the method showed great promise as a method for verification of RP in future patients. Trial registration: ClinicalTrials.gov NCT03094910.

KW - Diagnostic method

KW - Infrared thermographic imaging

KW - Primary Raynaud’s phenomenon

KW - Vibration white finger

UR - http://www.scopus.com/inward/record.url?scp=85107861744&partnerID=8YFLogxK

U2 - 10.3390/diagnostics11030558

DO - 10.3390/diagnostics11030558

M3 - Journal article

C2 - 33804657

VL - 11

JO - Diagnostics

JF - Diagnostics

SN - 2075-4418

IS - 3

M1 - 558

ER -

ID: 64862200