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Changes in tumor vascularity depicted by contrast-enhanced EUS as a predictor of prognosis and treatment efficacy in patients with unresectable pancreatic cancer (PEACE): A study protocol

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  • Adrian Sãftoiu
  • Manoop S Bhutani
  • Takao Itoi
  • Paolo G Arcidiacono
  • Erwan Bories
  • Irina M Cazacu
  • Alina Constantin
  • Emmanuel Coronel
  • Christoph F Dietrich
  • Dan G Duda
  • Julio Iglesias Garcia
  • Michael Hocke
  • Andre Ignee
  • Christian Jenssen
  • Mariana Jinga
  • Christopher Khor
  • Kofi W Oppong
  • Stephen Pereira
  • Maria Chiara Petrone
  • Erwin Santo
  • Andrada Seicean
  • Dong Wan Seo
  • Sun Siyu
  • Peter Vilmann
  • Irving Waxman
  • Paul Yeaton
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Patients with unresectable pancreatic cancer have a poor prognosis. The analysis of prognostic factors before treatment may be helpful in determining the best therapeutic strategies. The aim of the PEACE study is to assess the vascularity of pancreatic malignant tumors using contrast-enhanced harmonic EUS (CEH-EUS) and to clarify the prognostic value of tumor vascularity in patients with locally advanced and metastatic pancreatic cancer. Hereby, we present the protocol of a prospective, nonrandomized, single-arm, multicenter study aiming to assess changes in tumor vascularity using CEH-EUS before and 2 months after treatment initiation in patients with unresectable, locally advanced/metastatic pancreatic cancer and to examine the correlation between vascular changes and treatment response, progression-free survival, and overall survival.

Original languageEnglish
JournalEndoscopic Ultrasound
Volume8
Issue number4
Pages (from-to)235-240
Number of pages6
ISSN2303-9027
DOIs
Publication statusPublished - 30 Jun 2019

ID: 58975277