Changes in skin test reactivity among adults with atopic disease: a 3-year prospective study

Nina Aslund; Simon Francis Thomsen; Ellen Mølgaard; Hendrik Nolte; Vibeke Backer

doi:10.1016/S1081-1206(10)60292-X

Changes in skin test reactivity among adults with atopic disease: a 3-year prospective study

Nina Aslund, Simon Francis Thomsen, Ellen Mølgaard, Hendrik Nolte, Vibeke Backer

6 Citations (Scopus)

Abstract

BACKGROUND: Our knowledge about longitudinal predictors of atopy is limited.

OBJECTIVES: To describe changes in skin test reactivity during a 3-year period in a sample of adolescents and adults with atopic disease and to identify factors of importance for these changes.

METHODS: From a sample of 1,186 candidates, ranging in age from 14 to 44 years, who in a screening questionnaire reported symptoms suggestive of respiratory allergic disease, 344 individuals with a positive skin prick test (SPT) result concomitantly with asthma and/or rhinitis were clinically studied on 2 occasions, 3 years apart.

RESULTS: In total, 134 (39% of the study population) had a different SPT result at follow-up compared with baseline, based on a diagnostic criterion of 3 mm for a positive test result; 77 (22%) developed de novo sensitizations to 1 or more allergens, 45 (13%) had remission of 1 or more sensitizations, and 12 (4%) both gained and lost sensitizations. Female sex (odds ratio = 1.90 [1.02-3.57], P = .04) significantly predicted incidence of 1 or more sensitizations.

CONCLUSIONS: Four of 10 adults with atopic disease will have changes in SPT status during a 3-year period, and most will gain new sensitizations. Women with atopic disease are at increased risk of developing new sensitizations compared with men.

Original language	English
Journal	Annals of Allergy, Asthma, & Immunology
Volume	101
Issue number	5
Pages (from-to)	524-8
Number of pages	5
ISSN	1081-1206
DOIs	https://doi.org/10.1016/S1081-1206(10)60292-X
Publication status	Published - Nov 2008
Externally published	Yes

Keywords

Adolescent
Adult
Asthma/diagnosis
Female
Forced Expiratory Volume
Humans
Logistic Models
Male
Prospective Studies
Rhinitis, Allergic, Perennial/diagnosis
Skin Tests/methods
Urban Population
Young Adult

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10.1016/S1081-1206(10)60292-X

Cite this

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title = "Changes in skin test reactivity among adults with atopic disease: a 3-year prospective study",

abstract = "BACKGROUND: Our knowledge about longitudinal predictors of atopy is limited.OBJECTIVES: To describe changes in skin test reactivity during a 3-year period in a sample of adolescents and adults with atopic disease and to identify factors of importance for these changes.METHODS: From a sample of 1,186 candidates, ranging in age from 14 to 44 years, who in a screening questionnaire reported symptoms suggestive of respiratory allergic disease, 344 individuals with a positive skin prick test (SPT) result concomitantly with asthma and/or rhinitis were clinically studied on 2 occasions, 3 years apart.RESULTS: In total, 134 (39\% of the study population) had a different SPT result at follow-up compared with baseline, based on a diagnostic criterion of 3 mm for a positive test result; 77 (22\%) developed de novo sensitizations to 1 or more allergens, 45 (13\%) had remission of 1 or more sensitizations, and 12 (4\%) both gained and lost sensitizations. Female sex (odds ratio = 1.90 [1.02-3.57], P = .04) significantly predicted incidence of 1 or more sensitizations.CONCLUSIONS: Four of 10 adults with atopic disease will have changes in SPT status during a 3-year period, and most will gain new sensitizations. Women with atopic disease are at increased risk of developing new sensitizations compared with men.",

keywords = "Adolescent, Adult, Asthma/diagnosis, Female, Forced Expiratory Volume, Humans, Logistic Models, Male, Prospective Studies, Rhinitis, Allergic, Perennial/diagnosis, Skin Tests/methods, Urban Population, Young Adult",

author = "Nina Aslund and Thomsen, \{Simon Francis\} and Ellen M{\o}lgaard and Hendrik Nolte and Vibeke Backer",

year = "2008",

month = nov,

doi = "10.1016/S1081-1206(10)60292-X",

language = "English",

volume = "101",

pages = "524--8",

journal = "Annals of Allergy, Asthma, \& Immunology",

issn = "1081-1206",

publisher = "American College of Allergy, Asthma and Immunology",

number = "5",

}

TY - JOUR

T1 - Changes in skin test reactivity among adults with atopic disease

T2 - a 3-year prospective study

AU - Aslund, Nina

AU - Thomsen, Simon Francis

AU - Mølgaard, Ellen

AU - Nolte, Hendrik

AU - Backer, Vibeke

PY - 2008/11

Y1 - 2008/11

N2 - BACKGROUND: Our knowledge about longitudinal predictors of atopy is limited.OBJECTIVES: To describe changes in skin test reactivity during a 3-year period in a sample of adolescents and adults with atopic disease and to identify factors of importance for these changes.METHODS: From a sample of 1,186 candidates, ranging in age from 14 to 44 years, who in a screening questionnaire reported symptoms suggestive of respiratory allergic disease, 344 individuals with a positive skin prick test (SPT) result concomitantly with asthma and/or rhinitis were clinically studied on 2 occasions, 3 years apart.RESULTS: In total, 134 (39% of the study population) had a different SPT result at follow-up compared with baseline, based on a diagnostic criterion of 3 mm for a positive test result; 77 (22%) developed de novo sensitizations to 1 or more allergens, 45 (13%) had remission of 1 or more sensitizations, and 12 (4%) both gained and lost sensitizations. Female sex (odds ratio = 1.90 [1.02-3.57], P = .04) significantly predicted incidence of 1 or more sensitizations.CONCLUSIONS: Four of 10 adults with atopic disease will have changes in SPT status during a 3-year period, and most will gain new sensitizations. Women with atopic disease are at increased risk of developing new sensitizations compared with men.

AB - BACKGROUND: Our knowledge about longitudinal predictors of atopy is limited.OBJECTIVES: To describe changes in skin test reactivity during a 3-year period in a sample of adolescents and adults with atopic disease and to identify factors of importance for these changes.METHODS: From a sample of 1,186 candidates, ranging in age from 14 to 44 years, who in a screening questionnaire reported symptoms suggestive of respiratory allergic disease, 344 individuals with a positive skin prick test (SPT) result concomitantly with asthma and/or rhinitis were clinically studied on 2 occasions, 3 years apart.RESULTS: In total, 134 (39% of the study population) had a different SPT result at follow-up compared with baseline, based on a diagnostic criterion of 3 mm for a positive test result; 77 (22%) developed de novo sensitizations to 1 or more allergens, 45 (13%) had remission of 1 or more sensitizations, and 12 (4%) both gained and lost sensitizations. Female sex (odds ratio = 1.90 [1.02-3.57], P = .04) significantly predicted incidence of 1 or more sensitizations.CONCLUSIONS: Four of 10 adults with atopic disease will have changes in SPT status during a 3-year period, and most will gain new sensitizations. Women with atopic disease are at increased risk of developing new sensitizations compared with men.

KW - Adolescent

KW - Adult

KW - Asthma/diagnosis

KW - Female

KW - Forced Expiratory Volume

KW - Humans

KW - Logistic Models

KW - Male

KW - Prospective Studies

KW - Rhinitis, Allergic, Perennial/diagnosis

KW - Skin Tests/methods

KW - Urban Population

KW - Young Adult

UR - https://www.scopus.com/pages/publications/55849138701

U2 - 10.1016/S1081-1206(10)60292-X

DO - 10.1016/S1081-1206(10)60292-X

M3 - Journal article

C2 - 19055207

SN - 1081-1206

VL - 101

SP - 524

EP - 528

JO - Annals of Allergy, Asthma, & Immunology

JF - Annals of Allergy, Asthma, & Immunology

IS - 5

ER -

Changes in skin test reactivity among adults with atopic disease: a 3-year prospective study

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