Changes in forced expiratory volume in 1 second over time in COPD

Jørgen Vestbo, Lisa D Edwards, Paul D Scanlon, Julie C Yates, Alvar Agusti, Per Bakke, Peter M A Calverley, Bartolome Celli, Harvey O Coxson, Courtney Crim, David A Lomas, William MacNee, Bruce E Miller, Edwin K Silverman, Ruth Tal-Singer, Emiel Wouters, Stephen I Rennard, ECLIPSE Investigators

801 Citations (Scopus)

Abstract

A key feature of chronic obstructive pulmonary disease (COPD) is an accelerated rate of decline in forced expiratory volume in 1 second (FEV(1)), but data on the variability and determinants of this change in patients who have established disease are scarce.
Original languageEnglish
JournalNew England Journal of Medicine
Volume365
Issue number13
Pages (from-to)1184-92
Number of pages9
ISSN0028-4793
DOIs
Publication statusPublished - 2011

Keywords

  • Aged
  • Bayes Theorem
  • Biological Markers
  • C-Reactive Protein
  • Cytokines
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Forced Expiratory Volume
  • Humans
  • Male
  • Middle Aged
  • Models, Biological
  • Observation
  • Pulmonary Disease, Chronic Obstructive
  • Uteroglobin

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