Change in psoriatic arthritis outcome measures impacts SF-36 physical and mental component scores differently: an observational cohort study

Marie Skougaard; Tanja S Jørgensen; Mia J Jensen; Christine Ballegaard; Jørgen Guldberg-Møller; Alexander Egeberg; Robin Christensen; Peter Benzin; Zara R Stisen; Joseph F Merola; Laura C Coates; Vibeke Strand; Phillip Mease; Lars Erik Kristensen

doi:10.1093/rap/rkab076

Change in psoriatic arthritis outcome measures impacts SF-36 physical and mental component scores differently: an observational cohort study

Marie Skougaard, Tanja S Jørgensen, Mia J Jensen, Christine Ballegaard, Jørgen Guldberg-Møller, Alexander Egeberg, Robin Christensen, Peter Benzin, Zara R Stisen, Joseph F Merola, Laura C Coates, Vibeke Strand, Phillip Mease, Lars Erik Kristensen

Abstract

Objective: The objective was to investigate interplay and physical and mental component scores between change (Δ) in health-related quality of life (HRQoL) quantified by the physical component score (PCS) and mental component score (MCS) retrieved from short-form health survey (SF-36), change in disease activity (ΔDAS28CRP) and manifestations of PsA.

Methods: PsA patients initiating new medical therapy were enrolled. Independent disease measures evaluating disease activity, enthesitis, psoriasis, pain and fatigue were collected at treatment initiation and after 4 months. Interplay between independent disease measures and dependent outcome measures, ΔPCS and ΔMCS, was described with univariate regression analyses. Multivariate regression analyses were applied to assess the impact of independent variables, such as individual disease outcome measures vs ΔDAS28CRP on ΔPCS and ΔMCS.

Results: One hundred and eight PsA patients were included. In the univariate regression analyses, improvement in fatigue, pain and disability were associated with improvement in ΔPCS (β; -2.08, -0.18 and -13.00, respectively; all P < 0.001) and ΔMCS (β; -1.59, -0.12 and -6.07, respectively; P < 0.001, P < 0.001 and P = 0.003, respectively). When patient-reported outcomes were included in the final multivariate models, improvements in ΔPCS and ΔMCS were associated with improvements in pain, fatigue and disability (P < 0.001). Improvement in enthesitis impacted ΔPCS positively (β -0.31, P < 0.001). No association was found between change in skin psoriasis, ΔPCS and ΔMCS (β 0.15, P = 0.056 and β 0.05, P = 0.561, respectively).

Conclusion: In this PsA patient cohort, diminishing pain, disability and fatigue improved PCS and MCS significantly. Changes in enthesitis and psoriasis did not grossly impact HRQoL compared with DAS28CRP. Individual PsA manifestations influence HRQoL differently, which is important clinically when targeting treatment.

Trial registration: ClinicalTrials.gov, http://clinicaltrials.gov, NCT02572700.

Original language	English
Article number	rkab076
Journal	Rheumatology Advances in Practice
Volume	5
Issue number	3
Pages (from-to)	rkab076
ISSN	2514-1775
DOIs	https://doi.org/10.1093/rap/rkab076
Publication status	Published - 2021

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10.1093/rap/rkab076

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Skougaard, M., Jørgensen, T. S., Jensen, M. J., Ballegaard, C., Guldberg-Møller, J., Egeberg, A., Christensen, R., Benzin, P., Stisen, Z. R., Merola, J. F., Coates, L. C., Strand, V., Mease, P., & Kristensen, L. E. (2021). Change in psoriatic arthritis outcome measures impacts SF-36 physical and mental component scores differently: an observational cohort study. Rheumatology Advances in Practice, 5(3), rkab076. Article rkab076. https://doi.org/10.1093/rap/rkab076

Change in psoriatic arthritis outcome measures impacts SF-36 physical and mental component scores differently: an observational cohort study. / Skougaard, Marie ; Jørgensen, Tanja S; Jensen, Mia J et al.
In: Rheumatology Advances in Practice, Vol. 5, No. 3, rkab076, 2021, p. rkab076.

Research output: Contribution to journal › Journal article › Research › peer-review

Skougaard, M , Jørgensen, TS, Jensen, MJ, Ballegaard, C , Guldberg-Møller, J , Egeberg, A , Christensen, R, Benzin, P, Stisen, ZR, Merola, JF, Coates, LC, Strand, V, Mease, P & Kristensen, LE 2021, 'Change in psoriatic arthritis outcome measures impacts SF-36 physical and mental component scores differently: an observational cohort study', Rheumatology Advances in Practice, vol. 5, no. 3, rkab076, pp. rkab076. https://doi.org/10.1093/rap/rkab076

@article{b52095a71c784a158d5bbd0161a6f70e,

title = "Change in psoriatic arthritis outcome measures impacts SF-36 physical and mental component scores differently: an observational cohort study",

abstract = "Objective: The objective was to investigate interplay and physical and mental component scores between change (Δ) in health-related quality of life (HRQoL) quantified by the physical component score (PCS) and mental component score (MCS) retrieved from short-form health survey (SF-36), change in disease activity (ΔDAS28CRP) and manifestations of PsA.Methods: PsA patients initiating new medical therapy were enrolled. Independent disease measures evaluating disease activity, enthesitis, psoriasis, pain and fatigue were collected at treatment initiation and after 4 months. Interplay between independent disease measures and dependent outcome measures, ΔPCS and ΔMCS, was described with univariate regression analyses. Multivariate regression analyses were applied to assess the impact of independent variables, such as individual disease outcome measures vs ΔDAS28CRP on ΔPCS and ΔMCS.Results: One hundred and eight PsA patients were included. In the univariate regression analyses, improvement in fatigue, pain and disability were associated with improvement in ΔPCS (β; -2.08, -0.18 and -13.00, respectively; all P < 0.001) and ΔMCS (β; -1.59, -0.12 and -6.07, respectively; P < 0.001, P < 0.001 and P = 0.003, respectively). When patient-reported outcomes were included in the final multivariate models, improvements in ΔPCS and ΔMCS were associated with improvements in pain, fatigue and disability (P < 0.001). Improvement in enthesitis impacted ΔPCS positively (β -0.31, P < 0.001). No association was found between change in skin psoriasis, ΔPCS and ΔMCS (β 0.15, P = 0.056 and β 0.05, P = 0.561, respectively).Conclusion: In this PsA patient cohort, diminishing pain, disability and fatigue improved PCS and MCS significantly. Changes in enthesitis and psoriasis did not grossly impact HRQoL compared with DAS28CRP. Individual PsA manifestations influence HRQoL differently, which is important clinically when targeting treatment.Trial registration: ClinicalTrials.gov, http://clinicaltrials.gov, NCT02572700.",

author = "Marie Skougaard and J{\o}rgensen, {Tanja S} and Jensen, {Mia J} and Christine Ballegaard and J{\o}rgen Guldberg-M{\o}ller and Alexander Egeberg and Robin Christensen and Peter Benzin and Stisen, {Zara R} and Merola, {Joseph F} and Coates, {Laura C} and Vibeke Strand and Phillip Mease and Kristensen, {Lars Erik}",

note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology.",

year = "2021",

doi = "10.1093/rap/rkab076",

language = "English",

volume = "5",

pages = "rkab076",

journal = "Rheumatology Advances in Practice",

issn = "2514-1775",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Change in psoriatic arthritis outcome measures impacts SF-36 physical and mental component scores differently

T2 - an observational cohort study

AU - Skougaard, Marie

AU - Jørgensen, Tanja S

AU - Jensen, Mia J

AU - Ballegaard, Christine

AU - Guldberg-Møller, Jørgen

AU - Egeberg, Alexander

AU - Christensen, Robin

AU - Benzin, Peter

AU - Stisen, Zara R

AU - Merola, Joseph F

AU - Coates, Laura C

AU - Strand, Vibeke

AU - Mease, Phillip

AU - Kristensen, Lars Erik

PY - 2021

Y1 - 2021

N2 - Objective: The objective was to investigate interplay and physical and mental component scores between change (Δ) in health-related quality of life (HRQoL) quantified by the physical component score (PCS) and mental component score (MCS) retrieved from short-form health survey (SF-36), change in disease activity (ΔDAS28CRP) and manifestations of PsA.Methods: PsA patients initiating new medical therapy were enrolled. Independent disease measures evaluating disease activity, enthesitis, psoriasis, pain and fatigue were collected at treatment initiation and after 4 months. Interplay between independent disease measures and dependent outcome measures, ΔPCS and ΔMCS, was described with univariate regression analyses. Multivariate regression analyses were applied to assess the impact of independent variables, such as individual disease outcome measures vs ΔDAS28CRP on ΔPCS and ΔMCS.Results: One hundred and eight PsA patients were included. In the univariate regression analyses, improvement in fatigue, pain and disability were associated with improvement in ΔPCS (β; -2.08, -0.18 and -13.00, respectively; all P < 0.001) and ΔMCS (β; -1.59, -0.12 and -6.07, respectively; P < 0.001, P < 0.001 and P = 0.003, respectively). When patient-reported outcomes were included in the final multivariate models, improvements in ΔPCS and ΔMCS were associated with improvements in pain, fatigue and disability (P < 0.001). Improvement in enthesitis impacted ΔPCS positively (β -0.31, P < 0.001). No association was found between change in skin psoriasis, ΔPCS and ΔMCS (β 0.15, P = 0.056 and β 0.05, P = 0.561, respectively).Conclusion: In this PsA patient cohort, diminishing pain, disability and fatigue improved PCS and MCS significantly. Changes in enthesitis and psoriasis did not grossly impact HRQoL compared with DAS28CRP. Individual PsA manifestations influence HRQoL differently, which is important clinically when targeting treatment.Trial registration: ClinicalTrials.gov, http://clinicaltrials.gov, NCT02572700.

AB - Objective: The objective was to investigate interplay and physical and mental component scores between change (Δ) in health-related quality of life (HRQoL) quantified by the physical component score (PCS) and mental component score (MCS) retrieved from short-form health survey (SF-36), change in disease activity (ΔDAS28CRP) and manifestations of PsA.Methods: PsA patients initiating new medical therapy were enrolled. Independent disease measures evaluating disease activity, enthesitis, psoriasis, pain and fatigue were collected at treatment initiation and after 4 months. Interplay between independent disease measures and dependent outcome measures, ΔPCS and ΔMCS, was described with univariate regression analyses. Multivariate regression analyses were applied to assess the impact of independent variables, such as individual disease outcome measures vs ΔDAS28CRP on ΔPCS and ΔMCS.Results: One hundred and eight PsA patients were included. In the univariate regression analyses, improvement in fatigue, pain and disability were associated with improvement in ΔPCS (β; -2.08, -0.18 and -13.00, respectively; all P < 0.001) and ΔMCS (β; -1.59, -0.12 and -6.07, respectively; P < 0.001, P < 0.001 and P = 0.003, respectively). When patient-reported outcomes were included in the final multivariate models, improvements in ΔPCS and ΔMCS were associated with improvements in pain, fatigue and disability (P < 0.001). Improvement in enthesitis impacted ΔPCS positively (β -0.31, P < 0.001). No association was found between change in skin psoriasis, ΔPCS and ΔMCS (β 0.15, P = 0.056 and β 0.05, P = 0.561, respectively).Conclusion: In this PsA patient cohort, diminishing pain, disability and fatigue improved PCS and MCS significantly. Changes in enthesitis and psoriasis did not grossly impact HRQoL compared with DAS28CRP. Individual PsA manifestations influence HRQoL differently, which is important clinically when targeting treatment.Trial registration: ClinicalTrials.gov, http://clinicaltrials.gov, NCT02572700.

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U2 - 10.1093/rap/rkab076

DO - 10.1093/rap/rkab076

M3 - Journal article

C2 - 34778701

SN - 2514-1775

VL - 5

SP - rkab076

JO - Rheumatology Advances in Practice

JF - Rheumatology Advances in Practice

IS - 3

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ER -

Change in psoriatic arthritis outcome measures impacts SF-36 physical and mental component scores differently: an observational cohort study

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