Chalkley estimates of angiogenesis in early breast cancer--relevance to prognosis

Birgitte V Offersen, Flemming B Sørensen, Mette Yilmaz, Ann Knoop, Jens Overgaard, Danish Breast Cancer Cooperative Group Tumour Biology Committee

17 Citations (Scopus)

Abstract

The aim of this study was to investigate whether Chalkley estimates of angiogenesis add new knowledge regarding prediction of prognosis in 455 consecutive early breast carcinomas, both node-positive (52%) and node-negative (48%). Median follow-up was 101 months. Intense vascularization indicated poor disease-specific (p = 0.003) and overall (p = 0.004) survival. In node-negative patients, Chalkley counts were not associated with prognosis, whereas in node-positive patients, high Chalkley scores indicated poor disease-specific (p = 0.0006) and overall (p = 0.0008) survival. A multivariate analysis showed that positive lymph nodes, high histopathological grades, and negative oestrogen receptors were independent markers of cancer-related death. A high histopathological grade was associated with cancer-related death in node-negative patients, whereas in node-positive patients, many lymph nodes, high malignancy grade, negative oestrogen receptor, and increasing Chalkley counts (both tertiles and continuous) were independent markers of disease-specific death. Thus, in a univariate analysis it was found that high Chalkley estimates of angiogenesis indicated a poor prognosis, but high Chalkley estimates were independent prognostic markers only in node-positive patients.

Original languageEnglish
JournalActa Oncologica
Volume41
Issue number7-8
Pages (from-to)695-703
Number of pages9
ISSN0284-186X
Publication statusPublished - 2002

Keywords

  • Adult
  • Aged
  • Breast Neoplasms/mortality
  • Female
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry
  • Lymph Nodes/pathology
  • Middle Aged
  • Neovascularization, Pathologic/mortality
  • Prognosis
  • Survival Rate

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