CGRP receptor antagonist olcegepant (BIBN4096BS) does not prevent glyceryl trinitrate-induced migraine

Jesper Filtenborg Tvedskov, P Tfelt-Hansen, K A Petersen, Lars Thorbjørn Jensen, J Olesen

40 Citations (Scopus)

Abstract

There is a striking similarity between the migraine-provoking effect of the nitric oxide (NO) donor glyceryl trinitrate (GTN) and that of calcitonin gene-related peptide (CGRP). We tested the hypothesis that NO releases CGRP to cause the delayed migraine attack after GTN.
Original languageEnglish
JournalCephalalgia
Volume30
Issue number11
Pages (from-to)1346-53
Number of pages8
ISSN0333-1024
DOIs
Publication statusPublished - 1 Nov 2010

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