Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

CGRP as the target of new migraine therapies - successful translation from bench to clinic

Research output: Contribution to journalReviewpeer-review

  1. Calcitonin gene-related peptide - beyond migraine prophylaxis

    Research output: Contribution to journalComment/debateResearchpeer-review

  2. Ageing as a risk factor for neurodegenerative disease

    Research output: Contribution to journalReviewpeer-review

  3. Post-traumatic headache: epidemiology and pathophysiological insights

    Research output: Contribution to journalReviewpeer-review

  4. Does inflammation have a role in migraine?

    Research output: Contribution to journalReviewpeer-review

  1. Identifying New Antimigraine Targets: Lessons from Molecular Biology

    Research output: Contribution to journalReviewpeer-review

  2. Oral rimegepant for migraine prevention

    Research output: Contribution to journalComment/debateResearchpeer-review

View graph of relations

Treatment of migraine is on the cusp of a new era with the development of drugs that target the trigeminal sensory neuropeptide calcitonin gene-related peptide (CGRP) or its receptor. Several of these drugs are expected to receive approval for use in migraine headache in 2018 and 2019. CGRP-related therapies offer considerable improvements over existing drugs as they are the first to be designed specifically to act on the trigeminal pain system, they are more specific and they seem to have few or no adverse effects. CGRP receptor antagonists such as ubrogepant are effective for acute relief of migraine headache, whereas monoclonal antibodies against CGRP (eptinezumab, fremanezumab and galcanezumab) or the CGRP receptor (erenumab) effectively prevent migraine attacks. As these drugs come into clinical use, we provide an overview of knowledge that has led to successful development of these drugs. We describe the biology of CGRP signalling, summarize key clinical evidence for the role of CGRP in migraine headache, including the efficacy of CGRP-targeted treatment, and synthesize what is known about the role of CGRP in the trigeminovascular system. Finally, we consider how the latest findings provide new insight into the central role of the trigeminal ganglion in the pathophysiology of migraine.

Original languageEnglish
JournalNature reviews. Neurology
Volume14
Issue number6
Pages (from-to)338-350
Number of pages13
ISSN1759-4758
DOIs
Publication statusPublished - 2018

ID: 54579877