Cerebrospinal fluid glucose is not altered in patients with dementia

Camilla Steen Jensen; Helena Sophia Gleerup; Christian Sandøe Musaeus; Steen Hasselbalch; Peter Høgh; Gunhild Waldemar; Anja Hviid Simonsen

doi:10.1016/j.clinbiochem.2022.12.005

Cerebrospinal fluid glucose is not altered in patients with dementia

Camilla Steen Jensen, Helena Sophia Gleerup, Christian Sandøe Musaeus, Steen Hasselbalch, Peter Høgh, Gunhild Waldemar, Anja Hviid Simonsen^*

^*Corresponding author for this work

Neurology, Department of

Abstract

BACKGROUND: Studies have shown that the pathological changes of many dementia disorders begin several years before clinical onset. A connection between some of these pathophysiological changes and brain hypometabolism, seen in dementia disorders, is well established. Glucose is transported from the blood into the interstitial space, and the decreased demand for glucose by the degenerating brain tissue may thereby mirror increased levels of cerebrospinal fluid (CSF) glucose. In this study, the levels of CSF and plasma glucose and the CSF/plasma glucose ratio were investigated in a large cohort from a mixed memory clinic population in order to evaluate its diagnostic potential.

METHOD: CSF and plasma samples were taken from 446 patients (Alzheimer's Disease (AD) (n=320), vascular dementia (VaD) (n=64), frontotemporal dementia (FTD) (n=27) and dementia with Lewy bodies (DLB) (n=35)), and 130 healthy controls (HC) (healthy subjects (HS) (n=34), non-demented HS (n=96)).

RESULTS: No significant differences were found for CSF and plasma glucose or the CSF/plasma glucose ratio between patients with dementia disorders and HC. In addition, no significant differences were observed between the different dementia etiologies.

CONCLUSION: CSF and plasma glucose were not useful to differentiate between HC and patients with various dementia disorders.

Original language	English
Journal	Clinical Biochemistry
Volume	112
Pages (from-to)	1-5
Number of pages	5
ISSN	0009-9120
DOIs	https://doi.org/10.1016/j.clinbiochem.2022.12.005
Publication status	Published - 2023

Keywords

Alzheimer's disease
Cerebrospinal fluid
Dementia with Lewy bodies
Frontotemporal dementia
Glucose
Plasma
Vascular dementia

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10.1016/j.clinbiochem.2022.12.005

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title = "Cerebrospinal fluid glucose is not altered in patients with dementia",

abstract = "BACKGROUND: Studies have shown that the pathological changes of many dementia disorders begin several years before clinical onset. A connection between some of these pathophysiological changes and brain hypometabolism, seen in dementia disorders, is well established. Glucose is transported from the blood into the interstitial space, and the decreased demand for glucose by the degenerating brain tissue may thereby mirror increased levels of cerebrospinal fluid (CSF) glucose. In this study, the levels of CSF and plasma glucose and the CSF/plasma glucose ratio were investigated in a large cohort from a mixed memory clinic population in order to evaluate its diagnostic potential.METHOD: CSF and plasma samples were taken from 446 patients (Alzheimer's Disease (AD) (n=320), vascular dementia (VaD) (n=64), frontotemporal dementia (FTD) (n=27) and dementia with Lewy bodies (DLB) (n=35)), and 130 healthy controls (HC) (healthy subjects (HS) (n=34), non-demented HS (n=96)).RESULTS: No significant differences were found for CSF and plasma glucose or the CSF/plasma glucose ratio between patients with dementia disorders and HC. In addition, no significant differences were observed between the different dementia etiologies.CONCLUSION: CSF and plasma glucose were not useful to differentiate between HC and patients with various dementia disorders.",

keywords = "Alzheimer's disease, Cerebrospinal fluid, Dementia with Lewy bodies, Frontotemporal dementia, Glucose, Plasma, Vascular dementia",

author = "{Steen Jensen}, Camilla and {Sophia Gleerup}, Helena and {Sand{\o}e Musaeus}, Christian and Steen Hasselbalch and Peter H{\o}gh and Gunhild Waldemar and {Hviid Simonsen}, Anja",

note = "Copyright {\textcopyright} 2022. Published by Elsevier Inc.",

year = "2023",

doi = "10.1016/j.clinbiochem.2022.12.005",

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T1 - Cerebrospinal fluid glucose is not altered in patients with dementia

AU - Steen Jensen, Camilla

AU - Sophia Gleerup, Helena

AU - Sandøe Musaeus, Christian

AU - Hasselbalch, Steen

AU - Høgh, Peter

AU - Waldemar, Gunhild

AU - Hviid Simonsen, Anja

PY - 2023

Y1 - 2023

N2 - BACKGROUND: Studies have shown that the pathological changes of many dementia disorders begin several years before clinical onset. A connection between some of these pathophysiological changes and brain hypometabolism, seen in dementia disorders, is well established. Glucose is transported from the blood into the interstitial space, and the decreased demand for glucose by the degenerating brain tissue may thereby mirror increased levels of cerebrospinal fluid (CSF) glucose. In this study, the levels of CSF and plasma glucose and the CSF/plasma glucose ratio were investigated in a large cohort from a mixed memory clinic population in order to evaluate its diagnostic potential.METHOD: CSF and plasma samples were taken from 446 patients (Alzheimer's Disease (AD) (n=320), vascular dementia (VaD) (n=64), frontotemporal dementia (FTD) (n=27) and dementia with Lewy bodies (DLB) (n=35)), and 130 healthy controls (HC) (healthy subjects (HS) (n=34), non-demented HS (n=96)).RESULTS: No significant differences were found for CSF and plasma glucose or the CSF/plasma glucose ratio between patients with dementia disorders and HC. In addition, no significant differences were observed between the different dementia etiologies.CONCLUSION: CSF and plasma glucose were not useful to differentiate between HC and patients with various dementia disorders.

AB - BACKGROUND: Studies have shown that the pathological changes of many dementia disorders begin several years before clinical onset. A connection between some of these pathophysiological changes and brain hypometabolism, seen in dementia disorders, is well established. Glucose is transported from the blood into the interstitial space, and the decreased demand for glucose by the degenerating brain tissue may thereby mirror increased levels of cerebrospinal fluid (CSF) glucose. In this study, the levels of CSF and plasma glucose and the CSF/plasma glucose ratio were investigated in a large cohort from a mixed memory clinic population in order to evaluate its diagnostic potential.METHOD: CSF and plasma samples were taken from 446 patients (Alzheimer's Disease (AD) (n=320), vascular dementia (VaD) (n=64), frontotemporal dementia (FTD) (n=27) and dementia with Lewy bodies (DLB) (n=35)), and 130 healthy controls (HC) (healthy subjects (HS) (n=34), non-demented HS (n=96)).RESULTS: No significant differences were found for CSF and plasma glucose or the CSF/plasma glucose ratio between patients with dementia disorders and HC. In addition, no significant differences were observed between the different dementia etiologies.CONCLUSION: CSF and plasma glucose were not useful to differentiate between HC and patients with various dementia disorders.

KW - Alzheimer's disease

KW - Cerebrospinal fluid

KW - Dementia with Lewy bodies

KW - Frontotemporal dementia

KW - Glucose

KW - Plasma

KW - Vascular dementia

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DO - 10.1016/j.clinbiochem.2022.12.005

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SP - 1

EP - 5

JO - Clinical Biochemistry

JF - Clinical Biochemistry

SN - 0009-9120

ER -

Cerebrospinal fluid glucose is not altered in patients with dementia

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Keywords

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