Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Cerebrospinal Fluid Biomarkers to Differentiate Idiopathic Normal Pressure Hydrocephalus from Subcortical Ischemic Vascular Disease

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Neurofilament Light Chain Levels in Frontotemporal Dementia and Progressive Supranuclear Palsy: A Systematic Review

    Research output: Contribution to journalReviewResearchpeer-review

  2. Causes of Death in People with Dementia from 2002 to 2015: A Nationwide Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Comparing a Single Clinician Versus a Multidisciplinary Consensus Conference Approach for Dementia Diagnostics

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Dementia and COVID-19, a Bidirectional Liaison: Risk Factors, Biomarkers, and Optimal Health Care

    Research output: Contribution to journalReviewResearchpeer-review

  1. Hydrocephalus Study Design: Testing New Hypotheses in Clinical Studies and Bench-to-Bedside Research

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cerebrale manifestationer af tuberkulose

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Neurofilament Light Chain Levels in Frontotemporal Dementia and Progressive Supranuclear Palsy: A Systematic Review

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) remains a challenge to differentiate from subcortical ischemic vascular disease (SIVD). Despite major research efforts, the cerebrospinal fluid (CSF) biomarker profiles of the two diseases are still not known in detail.

OBJECTIVE: To determine if novel CSF biomarkers, neurofilament light (NFL) reflecting axonal damage, the synaptic protein neurogranin (NG), and the astroglial marker chitinase-3-like protein 1 (YKL-40), and the core Alzheimer's disease (AD) biomarkers, amyloid-β 42 (Aβ42), total tau (t-tau), phosphorylated tau (p-tau), can differentiate iNPH from SIVD. Patients with AD and healthy controls (HC) were included for comparison purposes.

METHODS: Patients with iNPH (n = 28), SIVD (n = 30), AD (n = 57), and HC (n = 33) were retrospectively included from the Danish Dementia Biobank. All patients with iNPH had effect of shunt surgery with a follow-up period of 4 to 69 months. CSF biomarkers were measured using immunoassays.

RESULTS: Lower levels of NFL, NG, Aβ42, and t-tau were found in patients with iNPH versus SIVD, while YKL-40 and p-tau were similar in the two diseases. NFL and Aβ42 were the most reliable biomarkers to differentiate iNPH from SIVD with an area under the curve (AUC) on 0.82 and 0.80, respectively. Combining NFL with Aβ42, t-tau, and p-tau resulted in an AUC of 0.90, which was equivalent to the diagnostic accuracy of all six biomarkers combined.

CONCLUSION: An addition of NFL to the CSF panel of Aβ42, t-tau, and p-tau may improve the differentiation of iNPH from SIVD.

Original languageEnglish
JournalJournal of Alzheimer's Disease
Volume75
Issue number3
Pages (from-to)937-947
Number of pages11
ISSN1387-2877
DOIs
Publication statusPublished - 2020

    Research areas

  • Biomarkers, cerebrospinal fluid, normal pressure hydrocephalus, vascular dementia

ID: 60062443