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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

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  3. PLASMA PRIMARY FATTY AMIDES ASSOCIATE TO CSF AMYLOID LEVELS AND ALZHEIMER’S DISEASE PROGRESSION IN THE EMIF-AD BIOMARKER DISCOVERY COHORT

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  • Isabelle Bos
  • Stephanie Vos
  • Frans Verhey
  • Philip Scheltens
  • Charlotte Teunissen
  • Sebastiaan Engelborghs
  • Kristel Sleegers
  • Giovanni Frisoni
  • Olivier Blin
  • Jill C Richardson
  • Régis Bordet
  • Magda Tsolaki
  • Julius Popp
  • Gwendoline Peyratout
  • Pablo Martinez-Lage
  • Mikel Tainta
  • Alberto Lleó
  • Peter Johannsen
  • Yvonne Freund-Levi
  • Lutz Frölich
  • Rik Vandenberghe
  • Sarah Westwood
  • Valerija Dobricic
  • Frederik Barkhof
  • Cristina Legido-Quigley
  • Lars Bertram
  • Simon Lovestone
  • Johannes Streffer
  • Ulf Andreasson
  • Kaj Blennow
  • Henrik Zetterberg
  • Pieter Jelle Visser
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INTRODUCTION: We investigated relations between amyloid-β (Aβ) status, apolipoprotein E (APOE) ε4, and cognition, with cerebrospinal fluid markers of neurogranin (Ng), neurofilament light (NFL), YKL-40, and total tau (T-tau).

METHODS: We included 770 individuals with normal cognition, mild cognitive impairment, and Alzheimer's disease (AD)-type dementia from the EMIF-AD Multimodal Biomarker Discovery study. We tested the association of Ng, NFL, YKL-40, and T-tau with Aβ status (Aβ- vs. Aβ+), clinical diagnosis APOE ε4 carriership, baseline cognition, and change in cognition.

RESULTS: Ng and T-tau distinguished between Aβ+ from Aβ- individuals in each clinical group, whereas NFL and YKL-40 were associated with Aβ+ in nondemented individuals only. APOE ε4 carriership did not influence NFL, Ng, and YKL-40 in Aβ+ individuals. NFL was the best predictor of cognitive decline in Aβ+ individuals across the cognitive spectrum.

DISCUSSION: Axonal degeneration, synaptic dysfunction, astroglial activation, and altered tau metabolism are involved already in preclinical AD. NFL may be a useful prognostic marker.

Original languageEnglish
JournalAlzheimer's & dementia : the journal of the Alzheimer's Association
Volume15
Issue number5
Pages (from-to)644-654
Number of pages11
ISSN1552-5260
DOIs
Publication statusPublished - 1 May 2019

    Research areas

  • Alzheimer's disease, Amyloid-β, APOE, Cerebrospinal fluid, Cognition, Neurofilament light, Neurogranin, YKL-40

ID: 56845185