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Cerebrospinal fluid beta-2-microglobulin in adult patients with acute leukemia or lymphoma: a useful marker in early diagnosis and monitoring of CNS-involvement

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  3. Optical coherence tomography in acute optic neuritis: A population-based study

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  4. Married, unmarried, divorced, and widowed and the risk of stroke

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  5. Phenotype and genotype of muscle ryanodine receptor rhabdomyolysis-myalgia syndrome

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  1. Patients' experiences and social support needs following the diagnosis and initial treatment of acute leukemia - A qualitative study

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  2. Hydrochloric acid prolongs the lifetime of central venous catheters in haematologic patients with bacteraemia

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  3. Interventional cohort study of prolonged use (>72 hours) of paracetamol in neonates: protocol of the PARASHUTE study

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  4. Obesity-induced CYP2E1 activity in children

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Beta-2-microglobulin (B2m) was measured in the cerebrospinal fluid (CSF) and serum from 18 adults with acute lymphoblastic leukemia, acute myeloblastic leukemia or lymphoma in order to detect early central nervous system (CNS) involvement or relapse. Six had CNS-involvement documented by neurologic symptoms and tumor cells in the CSF. Their CSF-B2m-concentrations were significantly higher before intrathecal chemotherapy than in those without this complication (P less than 0.01). During therapy CSF-B2m levels fell rapidly to normal values on repeated measurements. The study demonstrates that serial determination of CSF-B2m alone may be a useful and sensitive marker of CNS-dissemination in acute leukemia and malignant lymphoma. Using the criteria of CSF-B2m greater than 160 nmol/l as a positive diagnostic test the sensitivity of the test was 100%, the specificity was 76%. The same values for the CSF/serum-ratio greater than 1 were 75% and 64%, respectively.

Original languageEnglish
JournalActa Neurologica Scandinavica
Volume85
Issue number3
Pages (from-to)224-7
Number of pages4
ISSN0001-6314
Publication statusPublished - Mar 1992

    Research areas

  • Adult, Aged, Biomarkers, Tumor, Central Nervous System Neoplasms, Female, Hodgkin Disease, Humans, Leukemia, Leukemia, Myeloid, Acute, Lymphoma, Lymphoma, Non-Hodgkin, Male, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prospective Studies, beta 2-Microglobulin, Journal Article

ID: 49583723