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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Cerebrospinal fluid beta-2-microglobulin in adult patients with acute leukemia or lymphoma: a useful marker in early diagnosis and monitoring of CNS-involvement

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  2. Neurostimulation for the treatment of chronic migraine and cluster headache

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  3. Personality traits in migraine and medication-overuse headache: A comparative study

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  4. Treatment of spatial neglect in clinical practice: A nationwide survey

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  5. Optical coherence tomography in acute optic neuritis: A population-based study

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  1. Midazolam Pharmacokinetics in Obese and Non-obese Children and Adolescents

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  2. Pharmacogenetics of antiemetics for chemotherapy-induced nausea and vomiting: A systematic review and meta-analysis

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  3. Restriction of non-opioid analgesics sold over-the-counter in Denmark: A national study of impact on poisonings

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  4. The Risk of Drug-Drug Interactions with Paracetamol in a Population of Hospitalized Geriatric Patients

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Beta-2-microglobulin (B2m) was measured in the cerebrospinal fluid (CSF) and serum from 18 adults with acute lymphoblastic leukemia, acute myeloblastic leukemia or lymphoma in order to detect early central nervous system (CNS) involvement or relapse. Six had CNS-involvement documented by neurologic symptoms and tumor cells in the CSF. Their CSF-B2m-concentrations were significantly higher before intrathecal chemotherapy than in those without this complication (P less than 0.01). During therapy CSF-B2m levels fell rapidly to normal values on repeated measurements. The study demonstrates that serial determination of CSF-B2m alone may be a useful and sensitive marker of CNS-dissemination in acute leukemia and malignant lymphoma. Using the criteria of CSF-B2m greater than 160 nmol/l as a positive diagnostic test the sensitivity of the test was 100%, the specificity was 76%. The same values for the CSF/serum-ratio greater than 1 were 75% and 64%, respectively.

Original languageEnglish
JournalActa Neurologica Scandinavica
Volume85
Issue number3
Pages (from-to)224-7
Number of pages4
ISSN0001-6314
Publication statusPublished - Mar 1992

    Research areas

  • Adult, Aged, Biomarkers, Tumor, Central Nervous System Neoplasms, Female, Hodgkin Disease, Humans, Leukemia, Leukemia, Myeloid, Acute, Lymphoma, Lymphoma, Non-Hodgkin, Male, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prospective Studies, beta 2-Microglobulin, Journal Article

ID: 49583723