TY - JOUR
T1 - Cerebral perfusion, oxygenation and metabolism during exercise in young and elderly individuals
AU - Fisher, James P
AU - Hartwich, Doreen
AU - Seifert, Thomas
AU - Olesen, Niels
AU - McNulty, Clare L
AU - Nielsen, Henning M Bay
AU - van Lieshout, Johannes J
AU - Secher, Niels H
PY - 2013
Y1 - 2013
N2 - We evaluated cerebral perfusion, oxygenation, and metabolism in eleven young (age 22 ± 1 years) and nine older (age 66 ± 2 years) individuals at rest and during cycling exercise at low (25% W(max)), moderate (50% W(max)), high (75% W(ma)) and exhaustive (100% W(max)) workloads. Mean middle cerebral artery blood velocity (MCA V(mean)), mean arterial pressure (MAP), cardiac output (CO) and the partial pressure of arterial carbon dioxide (PaCO(2)) were measured. Blood samples were obtained from the right internal jugular vein and brachial artery to determine concentration differences for oxygen (O(2)), glucose and lactate across the brain. The molar ratio between the cerebral uptake of O(2) versus carbohydrate (O(2)-carbohydrate index; O(2) / [glucose + 0.5 lactate]; OCI), the cerebral metabolic rate of O(2) (CMRO(2)) and changes in mitochondrial O(2) tension (P(mito)O(2)) were calculated. W(max) was ~33% lower in the older group. Exercise increased MAP and CO in both groups (P
AB - We evaluated cerebral perfusion, oxygenation, and metabolism in eleven young (age 22 ± 1 years) and nine older (age 66 ± 2 years) individuals at rest and during cycling exercise at low (25% W(max)), moderate (50% W(max)), high (75% W(ma)) and exhaustive (100% W(max)) workloads. Mean middle cerebral artery blood velocity (MCA V(mean)), mean arterial pressure (MAP), cardiac output (CO) and the partial pressure of arterial carbon dioxide (PaCO(2)) were measured. Blood samples were obtained from the right internal jugular vein and brachial artery to determine concentration differences for oxygen (O(2)), glucose and lactate across the brain. The molar ratio between the cerebral uptake of O(2) versus carbohydrate (O(2)-carbohydrate index; O(2) / [glucose + 0.5 lactate]; OCI), the cerebral metabolic rate of O(2) (CMRO(2)) and changes in mitochondrial O(2) tension (P(mito)O(2)) were calculated. W(max) was ~33% lower in the older group. Exercise increased MAP and CO in both groups (P
U2 - 10.1113/jphysiol.2012.244905
DO - 10.1113/jphysiol.2012.244905
M3 - Journal article
C2 - 23230234
SN - 0022-3751
VL - 591
SP - 1859
EP - 1870
JO - Journal of Physiology
JF - Journal of Physiology
ER -