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Cerebral oxygenation and blood flow in term infants during postnatal transition: BabyLux project

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Harvard

De Carli, A, Andresen, B, Giovannella, M, Durduran, T, Contini, D, Spinelli, L, Weigel, UM, Passera, S, Pesenti, N, Mosca, F, Torricelli, A, Fumagalli, M & Greisen, G 2019, 'Cerebral oxygenation and blood flow in term infants during postnatal transition: BabyLux project' Archives of Disease in Childhood. Fetal and Neonatal Edition, vol. 104, no. 6, pp. F648-F653. https://doi.org/10.1136/archdischild-2018-316400

APA

CBE

De Carli A, Andresen B, Giovannella M, Durduran T, Contini D, Spinelli L, Weigel UM, Passera S, Pesenti N, Mosca F, Torricelli A, Fumagalli M, Greisen G. 2019. Cerebral oxygenation and blood flow in term infants during postnatal transition: BabyLux project. Archives of Disease in Childhood. Fetal and Neonatal Edition. 104(6):F648-F653. https://doi.org/10.1136/archdischild-2018-316400

MLA

Vancouver

Author

De Carli, Agnese ; Andresen, Björn ; Giovannella, Martina ; Durduran, Turgut ; Contini, Davide ; Spinelli, Lorenzo ; Weigel, Udo Michael ; Passera, Sofia ; Pesenti, Nicola ; Mosca, Fabio ; Torricelli, Alessandro ; Fumagalli, Monica ; Greisen, Gorm. / Cerebral oxygenation and blood flow in term infants during postnatal transition : BabyLux project. In: Archives of Disease in Childhood. Fetal and Neonatal Edition. 2019 ; Vol. 104, No. 6. pp. F648-F653.

Bibtex

@article{540228affa64427c92b20b7bc10bc10b,
title = "Cerebral oxygenation and blood flow in term infants during postnatal transition: BabyLux project",
abstract = "OBJECTIVES: A new device that combines, for the first time, two photonic technologies (time-resolved near-infrared spectroscopy and diffuse correlation spectroscopy) was provided and tested within the BabyLux project. Aim was to validate the expected changes in cerebral oxygenation and blood flow.METHODS: A pulse oximeter and the BabyLux device were held in place (right hand/wrist and frontoparietal region, respectively) for 10 min after birth in healthy term infants delivered by elective caesarean section. Pulse oximeter saturation (SpO2), cerebral tissue oxygen saturation (StO2) and blood flow index (BFI) were measured over time. Tissue oxygen extraction (TOE) and cerebral metabolic rate of oxygen index (CMRO2I) were calculated.RESULTS: Thirty infants were enrolled in two centres. After validity check of data, 23{\%} of infants were excluded from TOE and CMRO2I calculation due to missing data. As expected, SpO2 (estimate 3.05 {\%}/min; 95{\%} CI 2.78 to 3.31 {\%}/min) and StO2 (estimate 3.95 {\%}/min; 95{\%} CI 3.63 to 4.27 {\%}/min) increased in the first 10 min after birth, whereas BFI (estimate -2.84×10-9 cm2/s/min; 95{\%} CI -2.50×10-9 to -3.24×10-9 cm2/s/min) and TOE (estimate -0.78 {\%}/min; 95{\%} CI -1.12 to -0.45 {\%}/min) decreased. Surprisingly, CMRO2I decreased (estimate -7.94×10-8/min; 95{\%} CI -6.26×10-8 to -9.62×10-8/min).CONCLUSIONS: Brain oxygenation and BFI during transition were successfully and simultaneously obtained by the BabyLux device; no adverse effects were recorded, and the BabyLux device did not limit the standard care. The preliminary results from clinical application of the BabyLux device are encouraging in terms of safety and feasibility; they are consistent with previous reports on brain oxygenation during transition, although the interpretation of the decreasing CMRO2I remains open.TRIAL REGISTRATION NUMBER: NCT02815618.",
keywords = "cerebral blood flow, diffuse correlation spectroscopy, near-infrared spectroscopy, term infants, tissue oxygen saturation, Humans, Oximetry, Male, Brain/blood supply, Spectrum Analysis/instrumentation, Cesarean Section, Spectroscopy, Near-Infrared, Cerebrovascular Circulation/physiology, Female, Hemodynamics, Infant, Newborn, Oxygen/blood",
author = "{De Carli}, Agnese and Bj{\"o}rn Andresen and Martina Giovannella and Turgut Durduran and Davide Contini and Lorenzo Spinelli and Weigel, {Udo Michael} and Sofia Passera and Nicola Pesenti and Fabio Mosca and Alessandro Torricelli and Monica Fumagalli and Gorm Greisen",
note = "{\circledC} Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2019",
doi = "10.1136/archdischild-2018-316400",
language = "English",
volume = "104",
pages = "F648--F653",
journal = "Archives of Disease in Childhood: Fetal and Neonatal Edition",
issn = "1359-2998",
publisher = "B M J Group",
number = "6",

}

RIS

TY - JOUR

T1 - Cerebral oxygenation and blood flow in term infants during postnatal transition

T2 - BabyLux project

AU - De Carli, Agnese

AU - Andresen, Björn

AU - Giovannella, Martina

AU - Durduran, Turgut

AU - Contini, Davide

AU - Spinelli, Lorenzo

AU - Weigel, Udo Michael

AU - Passera, Sofia

AU - Pesenti, Nicola

AU - Mosca, Fabio

AU - Torricelli, Alessandro

AU - Fumagalli, Monica

AU - Greisen, Gorm

N1 - © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2019

Y1 - 2019

N2 - OBJECTIVES: A new device that combines, for the first time, two photonic technologies (time-resolved near-infrared spectroscopy and diffuse correlation spectroscopy) was provided and tested within the BabyLux project. Aim was to validate the expected changes in cerebral oxygenation and blood flow.METHODS: A pulse oximeter and the BabyLux device were held in place (right hand/wrist and frontoparietal region, respectively) for 10 min after birth in healthy term infants delivered by elective caesarean section. Pulse oximeter saturation (SpO2), cerebral tissue oxygen saturation (StO2) and blood flow index (BFI) were measured over time. Tissue oxygen extraction (TOE) and cerebral metabolic rate of oxygen index (CMRO2I) were calculated.RESULTS: Thirty infants were enrolled in two centres. After validity check of data, 23% of infants were excluded from TOE and CMRO2I calculation due to missing data. As expected, SpO2 (estimate 3.05 %/min; 95% CI 2.78 to 3.31 %/min) and StO2 (estimate 3.95 %/min; 95% CI 3.63 to 4.27 %/min) increased in the first 10 min after birth, whereas BFI (estimate -2.84×10-9 cm2/s/min; 95% CI -2.50×10-9 to -3.24×10-9 cm2/s/min) and TOE (estimate -0.78 %/min; 95% CI -1.12 to -0.45 %/min) decreased. Surprisingly, CMRO2I decreased (estimate -7.94×10-8/min; 95% CI -6.26×10-8 to -9.62×10-8/min).CONCLUSIONS: Brain oxygenation and BFI during transition were successfully and simultaneously obtained by the BabyLux device; no adverse effects were recorded, and the BabyLux device did not limit the standard care. The preliminary results from clinical application of the BabyLux device are encouraging in terms of safety and feasibility; they are consistent with previous reports on brain oxygenation during transition, although the interpretation of the decreasing CMRO2I remains open.TRIAL REGISTRATION NUMBER: NCT02815618.

AB - OBJECTIVES: A new device that combines, for the first time, two photonic technologies (time-resolved near-infrared spectroscopy and diffuse correlation spectroscopy) was provided and tested within the BabyLux project. Aim was to validate the expected changes in cerebral oxygenation and blood flow.METHODS: A pulse oximeter and the BabyLux device were held in place (right hand/wrist and frontoparietal region, respectively) for 10 min after birth in healthy term infants delivered by elective caesarean section. Pulse oximeter saturation (SpO2), cerebral tissue oxygen saturation (StO2) and blood flow index (BFI) were measured over time. Tissue oxygen extraction (TOE) and cerebral metabolic rate of oxygen index (CMRO2I) were calculated.RESULTS: Thirty infants were enrolled in two centres. After validity check of data, 23% of infants were excluded from TOE and CMRO2I calculation due to missing data. As expected, SpO2 (estimate 3.05 %/min; 95% CI 2.78 to 3.31 %/min) and StO2 (estimate 3.95 %/min; 95% CI 3.63 to 4.27 %/min) increased in the first 10 min after birth, whereas BFI (estimate -2.84×10-9 cm2/s/min; 95% CI -2.50×10-9 to -3.24×10-9 cm2/s/min) and TOE (estimate -0.78 %/min; 95% CI -1.12 to -0.45 %/min) decreased. Surprisingly, CMRO2I decreased (estimate -7.94×10-8/min; 95% CI -6.26×10-8 to -9.62×10-8/min).CONCLUSIONS: Brain oxygenation and BFI during transition were successfully and simultaneously obtained by the BabyLux device; no adverse effects were recorded, and the BabyLux device did not limit the standard care. The preliminary results from clinical application of the BabyLux device are encouraging in terms of safety and feasibility; they are consistent with previous reports on brain oxygenation during transition, although the interpretation of the decreasing CMRO2I remains open.TRIAL REGISTRATION NUMBER: NCT02815618.

KW - cerebral blood flow

KW - diffuse correlation spectroscopy

KW - near-infrared spectroscopy

KW - term infants

KW - tissue oxygen saturation

KW - Humans

KW - Oximetry

KW - Male

KW - Brain/blood supply

KW - Spectrum Analysis/instrumentation

KW - Cesarean Section

KW - Spectroscopy, Near-Infrared

KW - Cerebrovascular Circulation/physiology

KW - Female

KW - Hemodynamics

KW - Infant, Newborn

KW - Oxygen/blood

U2 - 10.1136/archdischild-2018-316400

DO - 10.1136/archdischild-2018-316400

M3 - Journal article

VL - 104

SP - F648-F653

JO - Archives of Disease in Childhood: Fetal and Neonatal Edition

JF - Archives of Disease in Childhood: Fetal and Neonatal Edition

SN - 1359-2998

IS - 6

ER -

ID: 58061215