Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Cerebral infarction after fractionated stereotactic radiation therapy of benign anterior skull base tumors

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Long term safety and visibility of a novel liquid fiducial marker for use in image guided radiotherapy of non-small cell lung cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The influence on survival of glucocorticoid induced diabetes in cancer patients with metastatic spinal cord compression

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Survival and failure types after radiation therapy of vulvar cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Intracranial pressure before and after cranioplasty: insights into intracranial physiology

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. B waves: a systematic review of terminology, characteristics, and analysis methods

    Research output: Contribution to journalReviewResearchpeer-review

  3. Hippocampal volume, cognitive functions, depression, anxiety, and quality of life in patients with Cushing's syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Thyroid Peroxidase Antibodies and Prospective Live Birth Rate: A Cohort Study of Women with Recurrent Pregnancy Loss

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background: The purpose of this study was to examine the occurrence of cerebral infarction (ischemic stroke), in a large combined cohort of patients with anterior skull base meningiomas, pituitary adenomas and craniopharyngiomas, after fractionated stereotactic radiation therapy (FSRT).

Material and Methods: All patients, 18 years and older, with anterior skull base meningiomas, pituitary adenomas and craniopharyngiomas, treated with fractionated stereotactic radiation, in our center, from January 1999 to December 2015 were identified. In total 169 patients were included. The prescription dose to the tumor was 54 Gy for 164 patients (97%) and 46.0-52.2 Gy for 5 patients (3%). Cases of cerebral infarctions subsequent to FSRT were identified from the Danish National Patient Registry and verified with review of case notes. The rate of cerebral infarction after FSRT was compared to the rate in the general population with a one sample t-test after standardization for age and year. We explored if age, sex, disease type, radiation dose and dose per fraction was associated with increased risk of cerebral infarction using univariate Cox models.

Results: At a median follow-up of 9.3 years (range 0.1-16.5), 7 of the 169 patients (4.1%) developed a cerebral infarction, at a median 5.7 years (range 1.2-11.5) after FSRT. The mean cerebral infarction rate for the general population was 0.0035 and 0.0048 for the FSRT cohort (p = 0.423). Univariate cox models analysis showed that increasing age correlated significantly with the cerebral infarction risk, with a hazard ratio of 1.090 (p = 0.013).

Conclusion: Increased risk of cerebral infarction after FSRT of anterior skull base tumors was associated with age, similar to the general population. Our study revealed that FSRT did not introduce an excess risk of cerebral infarction.

Original languageEnglish
JournalClinical and Translational Radiation Oncologi
Volume15
Pages (from-to)93-98
Number of pages6
ISSN2405-6308
DOIs
Publication statusPublished - Feb 2019

ID: 56740038