Cerebral energy metabolism during induced mitochondrial dysfunction

T H Nielsen; Tao Bindslev; S M Pedersen; P Toft; N V Olsen; Carl-Henrik Nordström

doi:10.1111/j.1399-6576.2012.02783.x

Cerebral energy metabolism during induced mitochondrial dysfunction

T H Nielsen, Tao Bindslev, S M Pedersen, P Toft, N V Olsen, Carl-Henrik Nordström

39 Citations (Scopus)

Abstract

In patients with traumatic brain injury as well as stroke, impaired cerebral oxidative energy metabolism may be an important factor contributing to the ultimate degree of tissue damage. We hypothesize that mitochondrial dysfunction can be diagnosed bedside by comparing the simultaneous changes in brain tissue oxygen tension (PbtO(2) ) and cerebral cytoplasmatic redox state. The study describes cerebral energy metabolism during mitochondrial dysfunction induced by sevoflurane in piglets.

Original language	English
Journal	Acta Anaesthesiologica Scandinavica
Volume	57
Issue number	2
Pages (from-to)	229-35
Number of pages	7
ISSN	0001-5172
DOIs	https://doi.org/10.1111/j.1399-6576.2012.02783.x
Publication status	Published - 2013

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10.1111/j.1399-6576.2012.02783.x

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AU - Toft, P

AU - Olsen, N V

AU - Nordström, Carl-Henrik

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Cerebral energy metabolism during induced mitochondrial dysfunction

Abstract

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