TY - JOUR
T1 - Centre for Statistical and Methodological Excellence (CESAME)
T2 - A Consortium Initiative for Improving Methodology in Randomised Clinical Trials
AU - Jørgensen, Caroline Kamp
AU - Olsen, Markus Harboe
AU - Nielsen, Niklas
AU - Lange, Theis
AU - Mbuagbaw, Lawrence
AU - Thabane, Lehana
AU - Billot, Laurent
AU - Binder, Nadine
AU - Garattini, Silvio
AU - Banzi, Rita
AU - Demotes, Jacques
AU - Biagioli, Elena
AU - Rulli, Eliana
AU - Bertolini, Guido
AU - Nattino, Giovanni
AU - Mathiesen, Ole
AU - Torri, Valter
AU - Gluud, Christian
AU - Jakobsen, Janus Christian
N1 - © The Author(s) 2023.
PY - 2023
Y1 - 2023
N2 - When conducting randomised clinical trials, the choice of methodology and statistical analyses will influence the results. If the planned methodology is not of optimal quality and predefined in detail, there is a risk of biased trial results and interpretation. Even though clinical trial methodology is already at a very high standard, there are many trials that deliver biased results due to the implementation of inadequate methodology, poor data quality and erroneous or biased analyses. To increase the internal and external validity of randomised clinical trial results, several international institutions within clinical intervention research have formed The Centre for Statistical and Methodological Excellence (CESAME). Based on international consensus, the CESAME initiative will develop recommendations for the proper methodological planning, conduct and analysis of clinical intervention research. CESAME aims to increase the validity of randomised clinical trial results which will ultimately benefit patients worldwide across medical specialities. The work of CESAME will be performed within 3 closely interconnected pillars: (1) planning randomised clinical trials; (2) conducting randomised clinical trials; and (3) analysing randomised clinical trials.
AB - When conducting randomised clinical trials, the choice of methodology and statistical analyses will influence the results. If the planned methodology is not of optimal quality and predefined in detail, there is a risk of biased trial results and interpretation. Even though clinical trial methodology is already at a very high standard, there are many trials that deliver biased results due to the implementation of inadequate methodology, poor data quality and erroneous or biased analyses. To increase the internal and external validity of randomised clinical trial results, several international institutions within clinical intervention research have formed The Centre for Statistical and Methodological Excellence (CESAME). Based on international consensus, the CESAME initiative will develop recommendations for the proper methodological planning, conduct and analysis of clinical intervention research. CESAME aims to increase the validity of randomised clinical trial results which will ultimately benefit patients worldwide across medical specialities. The work of CESAME will be performed within 3 closely interconnected pillars: (1) planning randomised clinical trials; (2) conducting randomised clinical trials; and (3) analysing randomised clinical trials.
UR - http://www.scopus.com/inward/record.url?scp=85153206128&partnerID=8YFLogxK
U2 - 10.1177/11786329231166519
DO - 10.1177/11786329231166519
M3 - Journal article
C2 - 37077323
SN - 1178-6329
VL - 16
JO - Health services insights
JF - Health services insights
M1 - 11786329231166519
ER -